NR1H4
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Official Full Name
nuclear receptor subfamily 1, group H, member 4 -
Overview
This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] -
Synonyms
NR1H4;nuclear receptor subfamily 1, group H, member 4;BAR;FXR;HRR1;HRR-1;RIP14;bile acid receptor;farnesol receptor HRR-1;RXR-interacting protein 14;farnesoid X nuclear receptor;farnesoid X-activated receptor;retinoid X receptor-interacting protein 14
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- E. coli
- Wheat Germ
- In Vitro Cell Free System
- GST
- Non
- His
- His&GST
- His&Fc&Avi
- His&SUMO
Involved Pathway
NR1H4 involved in several pathways and played different roles in them. We selected most pathways NR1H4 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1H4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | SLC2A1,ABCB1A,PRKACG,PRKACA,SLCO1A4,SLC4A4,SLC22A7,ATP1B2,ABCB4,KCNN2 |
Protein Function
NR1H4 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,bile acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1H4 itself. We selected most functions NR1H4 had, and list some proteins which have the same functions with NR1H4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TLL2,XIRP2,RABGGTB,CPB2,ING5,DPYS,BAZ2A,MAN2A1,GLO1,WHSC1L1 |
| transcriptional activator activity, RNA polymerase II transcription factor binding | CREB1,KLF14,SOX10,NFE2L1,CLOCK,KLF4,GBX2,PITX1,MIXL1,FOXH1 |
| transcription coactivator activity | MKL1,UBE2L3,PSMD9,ACTL6B,NFKB2,RAP2C,MED13,MED16,JMY,PML |
| retinoid X receptor binding | HMGA1,VDR,HMGA1-RS1,PPARG,RARG,NR0B2,FUS,RARB,NRIP1,NR1H2 |
| bile acid binding | AKR1C2,PLA2G1B,AKR1C21,FABP1,STARD5,FABP10A,PYGL,FABP6 |
| transcription factor activity, sequence-specific DNA binding | GABPB1,STAT3,TEF,NR2F6A,GAS7,TRPS1,ZFY1,GATAD2B,SLC12A9,SALL2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ISL1,MEOX1,FUBP3,CEBPG,LEF1,ZFP639,GCM1,MYOCD,SIX4,SFPI1 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | BACH1A,MED12,RUVBL2,BACH1,ESRRB,MEOX2,TAL1,NFE2L1,NONO,ATF2 |
| sequence-specific DNA binding | NKX6.1,MNX2A,FOXO3B,ZFP536,SPI1B,SIX2B,RORCA,FOXM1,MEIS3,FOXN2 |
Interacting Protein
NR1H4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1H4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1H4.
ESR1;GRB2;RELA;SMARCD1;abcbb_human_gene
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References
- Xia, X; Qu, B; et al. Analyzing time-series microarray data reveals key genes in spinal cord injury. MOLECULAR BIOLOGY REPORTS 41:6827-6835(2014).
- Yang, H; Jiang, J; et al. Molecular characterization, tissue expression profile and SNP analysis of the porcine NR1H4 gene. MOLECULAR BIOLOGY REPORTS 41:7009-7014(2014).
