NKX2-2
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Official Full Name
NK2 homeobox 2 -
Overview
Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene. Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. -
Synonyms
Nkx2.2;NKX2-2;NKX2.2;NKX2B;NK2 homeobox 2
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- His&Twin Strep&Flag
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NKX2-2-1303H | Recombinant Human NKX2-2, GST-tagged | E.coli | Human | GST | 1-129aa | |
| NKX2-2-3805H | Recombinant Human NKX2-2 protein, His-tagged | E.coli | Human | His | 1-129 aa | |
| NKX2-2-332H | Recombinant Human NKX2-2 Protein, His-tagged | E.coli | Human | His |
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| NKX2-2-5090C | Recombinant Chicken NKX2-2 | Mammalian Cells | Chicken | His |
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| NKX2-2-153H | Recombinant Human NK2 homeobox 2 Protein, His&Flag&StrepII tagged | E.coli | Human | His&Twin Strep&Flag | 20-128aa |
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| NKX2-2-1766M | Recombinant Mouse NKX2-2 Protein (1-273 aa), His-SUMO-tagged | E.coli | Mouse | His&SUMO | 1-273 aa |
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| NKX2-2-5896H | Recombinant Human NKX2-2 Protein, GST-tagged | Wheat Germ | Human | GST | 1-273 a.a. |
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| NKX2-2-6676HF | Recombinant Full Length Human NKX2-2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 273 amino acids |
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Involved Pathway
NKX2-2 involved in several pathways and played different roles in them. We selected most pathways NKX2-2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX2-2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NKX2-2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NKX2-2 itself. We selected most functions NKX2-2 had, and list some proteins which have the same functions with NKX2-2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
NKX2-2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX2-2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX2-2.
Resources
Research Area
Pancreatic Endoderm Cell MarkersNeural Stem Cell Transcription Factors
Endodermal Lineage Markers
Glioma Biomarkers
Related Services
Related Products
References
- Shibuya, R; Matsuyama, A; et al. The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma. VIRCHOWS ARCHIV 465:599-605(2014).
- Clark, JK; O'keefe, A; et al. Mammalian Nkx2.2(+) Perineurial Glia Are Essential for Motor Nerve Development. DEVELOPMENTAL DYNAMICS 243:1116-1129(2014).
