NCK1
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Official Full Name
NCK adaptor protein 1 -
Overview
NCK1 is one of the adaptor proteins which mediate specific protein-protein interactions in signaling processes. Adaptor proteins usually contain several domains like SH2 and SH3 which allow specific interactions with other specific proteins. NCK1 and NCK2 show high sequence identity (68%) and have three SH3 domains and a C-terminal SH2 domain. Both of them bind receptor tyrosine kinases such as PDGFR and other tyrosine phosphorylated proteins via their SH2 domains. Various molecules which interact with SH domains of Nck and regulate signaling process of actin cytoskeleton reorganization have been identified. Ncks are thought to have important functions in the development of mesodermal structures during embryogenesis, linked to a role in cell movement and cytoskeletal reorganization. Ncks also have a function in modulating mRNA translation at the level of initiation by interacting eukayotic initiation factor 2 (eIF2). Under stressed conditions, protein synthesis is reduced by inhibiting the activity of eIF2 through phosphorylation, transiently inhibiting recycling of eIF2 into its active form. -
Synonyms
NCK1;NCK adaptor protein 1;NCK;cytoplasmic protein NCK1;NCKalpha;NCK tyrosine kinase;melanoma NCK protein;SH2/SH3 adaptor protein NCK-alpha;non-catalytic region of tyrosine kinase;nck-1;MGC12668
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
NCK1 involved in several pathways and played different roles in them. We selected most pathways NCK1 participated on our site, such as ErbB signaling pathway,Axon guidance,T cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathogenic Escherichia coli infection | HCLS1,TUBA1A,TUBAL3,ARPC5L,ROCK1,TUBA3E,ACTB,ARHGEF2,CDC42,TUBB2A |
| Axon guidance | Sema3f,RAC1,FGF18B,FRS2B,DUSP4,NADL1.1,MAPK1,EGF,RGMA,SLIT2 |
| T cell receptor signaling pathway | GRB2,RHOA,FYN,NFKBIB,TEC,MAP2K1,VAV1,DEF6A,CDC42,MAP2K2 |
| ErbB signaling pathway | BADB,PRKCB,ERBB3,GRB2,SHC1,RAF1B,HBEGFA,ERBB4,AKT2,NCK2 |
Protein Function
NCK1 has several biochemical functions, for example, SH3/SH2 adaptor activity,cytoskeletal adaptor activity,eukaryotic initiation factor eIF2 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCK1 itself. We selected most functions NCK1 had, and list some proteins which have the same functions with NCK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase inhibitor activity | SH3BP5,SH3BP5B,TRIB2,GMFG,TSACC,SH3BP5L,TESC,SOCS9,GMFB,CHP1 |
| protein binding | ZCCHC7,SSBP1,ISOC2,SKA3,CST9L,CEP63,DHX36,LCE3C,ACYP2,PTPRZ1 |
| cytoskeletal adaptor activity | SORBS2,BAIAP2L1A,COX4I2,NCK2,ABI2,BAIAP2,BIN3,BICD1,BAIAP2A,BAIAP2L2B |
| SH3/SH2 adaptor activity | SH2D1A,SH2D2A,SOCS2,PTPN11,SH3BGRL,CRK,SH3BP2,PAG1,TOB1,SH2D3A |
| protein domain specific binding | SORBS2,CAPG,TACC3,HIST1H4N,TNFAIP1,HIST1H4H,HIST1H4I,VAPA,ZFP521,DICER1 |
| receptor signaling complex scaffold activity | SPAG9A,MAGI2,CD3E,MMS19,GRIP1,GRIP2A,DEDD2,SPAG9,ROPN1B,AXIN1 |
| protein binding, bridging | SH2D1B,TCAP,RAD50,BFAR,TRIM22,LOR,FSCN1,SPRR1A,AMFR,TJP2 |
| receptor tyrosine kinase binding | DOCK4,PIK3R2,ARHGEF16,Flt3l,PTPN1,GAS6,ANGPT2,PTPN14,CPNE3,PTPN11 |
| receptor binding | PLA2G1B,BAAT,GSTM2,LAMA4,SLC27A2,TNFSF12,CX3CL1,NSG1,PTK6B,HAMP |
Interacting Protein
NCK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCK1.
LCP2;CD3E
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