MMP13

What is mmp13 protein?

MMP13 is mainly produced by chondrocytes, cells within cartilage, and plays an important role in cartilage remodeling and breakdown during development and growth. It is involved in endochondral ossification, the process by which bones are formed from cartilage templates. MMP13 action breaks down cartilage to allow its replacement with bone. Increased MMP13 expression/activity has been implicated in diseases involving cartilage degradation like osteoarthritis. It is a Marker of disease progression.MMP13 can also degrade other matrix proteins apart from collagens like aggrecan and pericellular matrix. Its activity is regulated at multiple levels including transcription, activation of zymogen, and inhibition by tissue inhibitors of metalloproteinases (TIMPs).

What are the functions of MMP13 protein?

Cartilage breakdown: MMP13 is specialized in degrading type II collagen, which is the most abundant collagen in cartilage. It breaks down the collagen network in cartilage.

Bone development: MMP13 plays an important role in endochondral ossification by degrading cartilage templates to allow their replacement with bone. This allows for proper bone growth and modeling.

Tissue remodeling: Along with collagen degradation, MMP13 can also cleave other extracellular matrix proteins like aggrecan. This allows for tissue remodeling during development, growth and wound healing.

Arthritis: Increased MMP13 expression and activity leads to excess cartilage breakdown in arthritic conditions like osteoarthritis. It contributes to disease pathogenesis.

MMP13 related signaling pathway

MAPK pathway: MMP13 expression is regulated by the MAPK signaling cascade, especially the ERK1/2 and p38 pathways. Factors like IL-1β and TGF-β induce MMP13 via MAPKs.

NF-κB pathway: Inflammatory cytokines like IL-1β activate NF-κB signaling to upregulate MMP13 transcription. NF-κB binds to MMP13 promoter region.

Wnt/β-catenin pathway: Wnt ligands induce β-catenin nuclear translocation and transcriptional activation of MMP13. This pathway mediates MMP13 expression in arthritis.

Notch pathway: Notch intracellular domain binds to RBP-Jκ and induces MMP13 expression in chondrocytes and osteoblasts during skeletal development.

MMP13 Related Diseases

•  Osteoarthritis: Increased MMP13 expression contributes to cartilage degradation in osteoarthritis. It is a marker for disease progression.
•  Rheumatoid arthritis: MMP13 levels correlate with joint damage in RA. Inhibiting it may help slow disease progression.
•  Developmental skeletal diseases: Mutations affecting MMP13 cause polymorphic chondrodysplasias due to impaired endochondral ossification.
•  Cancer metastasis: Many cancers like gastric, breast and prostate show elevated MMP13. It promotes tumor cell invasion and metastasis.
•  Periodontitis: MMP13 levels increase in gingival crevicular fluid of periodontitis patients, destroying ligament and bone tissues.
•  Disease biomarker: MMP13 levels can serve as an indicator of disease progression in osteoarthritis, rheumatoid arthritis and cancer metastasis.
•  Drug target: Developing selective MMP13 inhibitors is a promising approach for arthritis and cancer therapeutic intervention.
•  Tissue engineering: Regulations of MMP13 activity could promote cartilage regeneration for treating osteoarthritis and other joint disorders.

•  Disease biomarker: MMP13 levels can serve as an indicator of disease progression in osteoarthritis, rheumatoid arthritis and cancer metastasis.
•  Drug target: Developing selective MMP13 inhibitors is a promising approach for arthritis and cancer therapeutic intervention.
•  Tissue engineering: Regulations of MMP13 activity could promote cartilage regeneration for treating osteoarthritis and other joint disorders.

MMP13 has several biochemical functions, for example, calcium ion binding,calcium-dependent protein binding,collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP13 itself. We selected most functions MMP13 had, and list some proteins which have the same functions with MMP13. You can find most of the proteins on our site.

MMP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP13.