MANF
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Official Full Name
mesencephalic astrocyte-derived neurotrophic factor -
Overview
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. -
Synonyms
ARP;ARMET;MGC142148;MGC142150;mesencephalic astrocyte-derived neurotrophic factor;OTTHUMP00000210954;arginine-rich, mutated in early stage tumors
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Human Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- CHO
- In Vitro Cell Free System
- Non
- His
- GST
- Fc
- DDK&Myc
- Avi&Fc&His
Involved Pathway
MANF involved in several pathways and played different roles in them. We selected most pathways MANF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MANF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MANF has several biochemical functions, for example, growth factor activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MANF itself. We selected most functions MANF had, and list some proteins which have the same functions with MANF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | HBEGF,FGF16,NODAL,IL5,PTN,GDF10,BMP16,GRN,BMP6,GMFG |
| poly(A) RNA binding | APOBEC3C,RPS13,MYH9,HIST1H1D,NUCKS1,MRPS28,LSM3,RPS2,EMG1,AGO2 |
Interacting Protein
MANF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MANF here. Most of them are supplied by our site. Hope this information will be useful for your research of MANF.
IKBKE;ZDHHC17;Racgap1
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