LRP5
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Official Full Name
low density lipoprotein receptor-related protein 5 -
Overview
WNT proteins have diverse roles in governing cell fate, proliferation, migration, polarity and death. WNT signaling controls development and is important for embryogenesis and carcinogenesis1-3. WNTs are transduced through at least three distinct intracel -
Synonyms
LRP5;low density lipoprotein receptor-related protein 5;EVR1, exudative vitreoretinopathy 1 , LRP7, OPPG, osteoporosis pseudoglioma syndrome;low-density lipoprotein receptor-related protein 5;BMND1;HBM;LR3;OPS;LRP-5;low density lipoprotein rece
Recombinant Proteins
- Mouse
- Human
- Rat
- Chicken
- Zebrafish
- HEK293
- Wheat Germ
- E.coli
- Mammalian Cells
- His
- Non
- Fc
- Avi&His
- Avi&Fc&His
- DDK&Myc
- Flag
- mFc
- GST
Involved Pathway
LRP5 involved in several pathways and played different roles in them. We selected most pathways LRP5 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | CHD8,VANGL2,PRKACA,WNT5A,PSEN1,SFRP1A,CAMK2D,CAMK2B,PORCN,FZD6 |
Protein Function
LRP5 has several biochemical functions, for example, Wnt-activated receptor activity,Wnt-protein binding,coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP5 itself. We selected most functions LRP5 had, and list some proteins which have the same functions with LRP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Wnt-protein binding | FZD9B,CTHRC1,SFRP1B,GPR177,SZL,FZD7,FZD7A,FZD8A,FZD8B,APCDD1 |
| Wnt-activated receptor activity | FZD8B,FZD10,LRP5L,FZD9,FZD3A,FZD7B,FZD7A,FZD2,FZD3,LRP2A |
| NOT toxin transporter activity | LRP6 |
| coreceptor activity | CD4,ACKR3B,LY96,PVRL2,PVRL1,CXCR4,CD28,IGSF1,CCR8,CCR5 |
| protein binding | SLC25A5,BUB3,VPS18,HIST2H3C,SULT1C2,SARM1,FZD5,VAMP3,HIF1A,SLX4 |
Interacting Protein
LRP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP5.
SOST;CAPRIN2;Fzd8;Mesdc2;SMAD9;BALF4 (provisional);q81ye8_bacan;NDP
LRP5 Related Signal Pathway
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References
- Whyte, MP; Madson, KL; et al. Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis. JOURNAL OF BONE AND MINERAL RESEARCH 29:2601-2609(2014).
- Tella, SH; Gallagher, JC; et al. Biological agents in management of osteoporosis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 70:1291-1301(2014).
