LRP2
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Official Full Name
low density lipoprotein receptor-related protein 2 -
Overview
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR). -
Synonyms
LRP2;low density lipoprotein receptor-related protein 2;low-density lipoprotein receptor-related protein 2;DBS;gp330;megalin;LRP-2;glycoprotein 330;calcium sensor protein;Heymann nephritis antigen homolog
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Yeast
- HEK293
- His
- His&Fc&Avi
- mFc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LRP2-27H | Recombinant Human LRP2 Protein, His-tagged | E.coli | Human | His | Gly4035~Leu4184 | |
| LRP2-3453R | Recombinant Rat LRP2 Protein | Mammalian Cell | Rat | His |
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| LRP2-9234M | Recombinant Mouse LRP2 Protein | Mammalian Cell | Mouse | His |
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| LRP2-1448H | Recombinant Human LRP2 Protein (1186-1389 aa), His-tagged | Yeast | Human | His | 1186-1389 aa |
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| LRP2-2811H | Recombinant Human LRP2 protein(4531-4600 aa), C-His-tagged | E.coli | Human | His | 4531-4600 aa |
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| LRP2-3109R | Recombinant Rat LRP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| LRP2-3109R-B | Recombinant Rat LRP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| LRP2-5162M | Recombinant Mouse LRP2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LRP2-5162M-B | Recombinant Mouse LRP2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| LRP2-7443H | Recombinant Human LRP2 protein, His-tagged | Yeast | Human | His | 1186-1389aa |
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| LRP2-8754H | Recombinant Human LRP2 protein, mFc-tagged | HEK293 | Human | mFc | 1186-1389aa |
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Involved Pathway
LRP2 involved in several pathways and played different roles in them. We selected most pathways LRP2 participated on our site, such as Hedgehog signaling pathway,Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | ASGR1,ITPR3,TSHR,GSR,TSHB,PDIA4,GNAQ,ASGR2,CREB5,ITPR1 |
| Hedgehog signaling pathway | DHH,SMO,WNT8B,WNT2BA,GLI1,PRKACAB,PRKACBA,LRP2A,ZIC2,WNT3 |
Protein Function
LRP2 has several biochemical functions, for example, PDZ domain binding,SH3 domain binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP2 itself. We selected most functions LRP2 had, and list some proteins which have the same functions with LRP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | NRXN3,V1RA8,TNFRSF25,PAQR3A,SLC20A1,PVRL4,GRIA4B,P2RY2,MED16,CD40 |
| hormone binding | ADIPOR1A,GPR30,ADIPOR2,AMHR2,MTNR1A,NPR1,MC5R,UCN2,CRYM,ADIPOR1B |
| calcium ion binding | MMP16,KCNIP3A,MFGE8A,PCDH2G4,PCDHB12,HSPA5,ATP2A2,MYL12.1,PLCD1,MYL4 |
| SH3 domain binding | PARK2,SOS1,ARHGAP1,CCDC6,EVLB,TOM1L1,CBL,INPP5J,INPPL1,PDE4D |
| protein binding | NFAT5,KIF21A,DTX2,DRAM1,UCN,TRIM27,MEIOB,APOH,HIST1H2BE,MC3R |
| hemoglobin binding | AHSP,CUBN,HP,HBB,HPR |
| low-density lipoprotein particle receptor binding | APOEA,HSP90B1,MESDC2,LRPAP1,DNAJA1,PCSK9,AP2M1,SNX17,LDLRAP1,APOEB |
| PDZ domain binding | FZD7,DLG1,PLEKHA1,GRIA1,PTEN,GNG5,TGFBR3,LIN7C,SNTB1,LPAR2 |
| protein complex binding | NFKBIA,RPTOR,ITGB1BP1,ITPR1,KRT8,ABI2,ST13,TUB,VHLL,RNF40 |
Interacting Protein
LRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP2.
Dab1;Dlg4;Synj2bp;Mapk8ip2;Mapk8ip1;Gipc1;Gm10174;Anapc10;Ywhaz;Hsd3b4;Rpgrip1l
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References
- Pieper-Furst, U; Hall, R; et al. Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1812:1640-1648(2011).
- Fujiyoshi, M; Tachikawa, M; et al. Amyloid-beta peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. JOURNAL OF NEUROCHEMISTRY 118:407-415(2011).
