LILRB2
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Official Full Name
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 -
Overview
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
LILRB2;leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2;leukocyte immunoglobulin-like receptor subfamily B member 2;CD85d;ILT4;LIR 2;LIR2;MIR 10;MIR10;ILT-4;Ig-like transcript 4;immunoglobulin-like transcript 4;CD85 antigen-like family member D;leukocyte immunoglobulin-like receptor 2;monocyte/macrophage immunoglobulin-like receptor 10;leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform;eukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6;LIR-2;LILRA6;MIR-10
Recombinant Proteins
- Human
- Cynomolgus
- E.coli
- HEK293
- Mammalian cells
- Human Cell
- HEK293T
- GST
- Non
- Fc&Avi
- Fc
- His
- mFc
- His&Avi
- C-His&Flag
- His&Fc&Avi
- Myc&DDK
- His&Myc
Involved Pathway
LILRB2 involved in several pathways and played different roles in them. We selected most pathways LILRB2 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | SYK,IL1A,CSF1,TEC,STAT2,FCGR3B,NFKB2,SQSTM1,IFNAR2,TNF |
| Adaptive Immune System | GRAP2A,CXADR,HLA-DQB2,CD300LB,HECTD3,CDKN1B,SH3RF1,ICAM4,CD300E,TRIM50 |
| Immune System | ARIH2,KIF4,NCR3LG1,GRAP2B,CTSE,ARIH1,PAG1,S100A12,IGHM,TRIM38 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | LILRB1,KLRB1A,CLEC2G,AMICA1,LILRA2,CLEC2H,KLRG1,CD200R2,KLRB1B,LILRB5 |
Protein Function
LILRB2 has several biochemical functions, for example, MHC class I protein binding,MHC class Ib protein binding,cell adhesion molecule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRB2 itself. We selected most functions LILRB2 had, and list some proteins which have the same functions with LILRB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | CD200,ANXA2R,ADIPOR2,SLC20A2,CUL5,KLRK1,MED17,RRBP1B,CD40,CADM1 |
| MHC class I protein binding | LILRB1,ATP5A1,TUBB,BCAP31,VCP,TUBB4B,Pilrb1,DERL1,ATP5B,TAPBP |
| cell adhesion molecule binding | PVRL3,LPHN1,FGFR1,ITGB3,PVRL4,NLGN1,ADAM8,FGG,NLGN4X,NCR3 |
| protein phosphatase 1 binding | PHACTR3A,SHOC2,PPP1R15A,PHACTR1,PPP1R9B,PPP1R11,Fert2,PHACTR3B,STAU1,PAWR |
| protein binding | HDAC6,USP25,SGK1,PTPRJ,GNMT,DKK1B,SMC6,RWDD3,FES,CSPG5 |
| MHC class Ib protein binding | TAP2,TAP1 |
Interacting Protein
LILRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRB2.
metA;ppsA;pdaA
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