LHB
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Official Full Name
luteinizing hormone beta polypeptide -
Overview
Luteinizing Hormone is a member of the glycoprotein hormone beta chain family. Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. Luteinizing Hormone is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. -
Synonyms
CGB4;hLHB;LSH-B;Luteinizing Hormone (hLH) Beta Core Fragment;luteinizing hormone beta polypeptide;LHB
Recombinant Proteins
- Zebrafish
- Human
- Cynomolgus
- Rat
- Mouse
- Dog
- Bovine
- Mammalian Cell
- HEK293
- E.coli
- Mouse
- HEK293 cells
- CHO
- HEK293T
- Pituitary Gland
- His
- Myc&DDK
- His&T7
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
LHB involved in several pathways and played different roles in them. We selected most pathways LHB participated on our site, such as Neuroactive ligand-receptor interaction,GnRH signaling pathway,Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | OPRD1,TAAR10C,ADORA2AA,VIPR1B,GLP1R,FSHR,CHRNA4,GRIN2BB,TAAR8B,CHRNA10 |
| Ovarian steroidogenesis | PLA2G4A,HSD17B7,BMP15,LDLR,IGF1,FSHB,HSD3B5,PLA2G4C,GDF9,AKR1C3 |
| Prolactin signaling pathway | CSH,INS,SOCS1,MAPK11,PIK3R1,ESR2,CSN2,MAP2K2,IRF1,STAT5A |
| GnRH signaling pathway | CALM3B,CALM3A,MAPK9,PTK2BB,MAPK11,PRKACAB,GRB2B,ADCY2B,PLA2G4AA,CALML5 |
Protein Function
LHB has several biochemical functions, for example, hormone activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LHB itself. We selected most functions LHB had, and list some proteins which have the same functions with LHB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | ARRB2,MATK,TNFSF10,PPP2R4,DAO1,Ar,FGF18B,AGRP2,HAND2,FYNA |
| hormone activity | CSH1,IAPP,GPHA2,PRL4A1,PRL8A9,BNP,URP2,INS,INS-IGF2,GNRH1 |
Interacting Protein
LHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LHB here. Most of them are supplied by our site. Hope this information will be useful for your research of LHB.
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References
- Cui, W; Mizukami, HP; et al. Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance. JOURNAL OF NEUROSCIENCE 34:16273-16285(2014).
- Reddy, A; May, E; et al. Latent hepatitis B is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C. WORLD JOURNAL OF GASTROENTEROLOGY 19:9328-9333(2013).
