LAMTOR3
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Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -
Overview
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. -
Synonyms
MP1;MAPBP;MAPKSP1;MAP2K1IP1;Ragulator3;ragulator complex protein LAMTOR3;PRO0633;MEK partner 1;OTTHUMP00000161681;OTTHUMP00000219461;MEK binding partner 1;MEK-binding partner 1;MAPK scaffold protein 1;mitogen-activated protein kinase scaffold protein 1;late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;mitogen-activated protein kinase kinase 1 interacting protein 1;mitogen-activated protein kinase kinase 1-interacting protein 1;LAMTOR3
Recombinant Proteins
- Chicken
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cell
- E.coli
- Human
- HEK293
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
LAMTOR3 involved in several pathways and played different roles in them. We selected most pathways LAMTOR3 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMTOR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | EGFRA,MKNK2B,MAP3K14,RPS6KAL,CACNG2A,MAPK8IP3,RELA,MAP3K4,ARR3A,FOS |
Protein Function
LAMTOR3 has several biochemical functions, for example, contributes_to guanyl-nucleotide exchange factor activity,protein binding,contributes_to protein complex scaffold. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMTOR3 itself. We selected most functions LAMTOR3 had, and list some proteins which have the same functions with LAMTOR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to guanyl-nucleotide exchange factor activity | EIF2B4,ALS2,LAMTOR1,HBXIP,EIF2B3,LAMTOR2,EIF2B5,EIF2B2,C7orf59,EIF2B1 |
| contributes_to protein complex scaffold | C7orf59,LAMTOR1,HBXIP,LAMTOR2 |
| protein binding | PPP3R1,KLHL38,PPP4C,HSPA5,MRAS,ZP3,FAM193B,RAB41,PRUNE,NABP1 |
Interacting Protein
LAMTOR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMTOR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMTOR3.
LAMTOR2;RRAGB;RRAGC
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