KREMEN1
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Official Full Name
kringle containing transmembrane protein 1 -
Overview
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WN -
Synonyms
KREMEN1;kringle containing transmembrane protein 1;KREMEN, kringle containing transmembrane protein;kremen protein 1;KRM1;dickkopf receptor;kringle-coding gene marking the eye and the nose;kringle domain-containing transmembrane protein 1;kringle
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Human Cell
- HEK293
- Mammalian Cell
- E.coli
- HEK293T
- Wheat Germ
- Fc
- His
- His&T7
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
KREMEN1 involved in several pathways and played different roles in them. We selected most pathways KREMEN1 participated on our site, such as Disease,Diseases of signal transduction,Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with KREMEN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TCF dependent signaling in response to WNT | LEO1,KLHL12,BCL9L,USP34,RNF43,WNT8-2,SOX4B,SOX32,CDC73,WIF1 |
| Signaling by WNT in cancer | KREMEN2,TNKS,RNF43,TNKS2 |
| Diseases of signal transduction | LRRFIP1,TNKS2,RNF43,FGFR1OP2,TRAT1,TNKS,TRIM24,STRA6,RLBP1,KREMEN2 |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | WIF1,KREMEN2 |
| Signaling by Wnt | PRICKLE1,RSPO2,RSPO4,LEO1,RYK,SOX4A,GPR177,SOX13,LGR6,DACT1 |
| Signal Transduction | KIF7,USP4,IGF2BP1,GPR65,PRC1,CRABP2A,CCNT2B,EVL,TLE3B,ARAP2 |
| Disease | NMT2,NUP35,CPSF4,ANTXR2,PRELP,OPN1MW,TLR10,OPN1SW,MMAA,COBRA1 |
| Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling | KREMEN2 |
Protein Function
KREMEN1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KREMEN1 itself. We selected most functions KREMEN1 had, and list some proteins which have the same functions with KREMEN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CXADR,TRAM2,KRTAP4-11,ZNF434,FIG4,PRKG1,DRAM1,MCC,GSS,PIWIL1 |
Interacting Protein
KREMEN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KREMEN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KREMEN1.
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