KIR3DL1
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Official Full Name
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 -
Overview
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. -
Synonyms
KIR3DL1;killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1;KIR;killer cell immunoglobulin-like receptor 3DL1;AMB11;CD158e1;CD158e1/2;CD158e2;cl 2;cl 11;nkat3;NKB1;NKB1B;CD158 antigen-like family member E;CD158E;CD158e antigen;CL11;CL2;HLA-BW4-specific inhibitory NK cell receptor;killer cell immunoglobulin like receptor;Killer cell immunoglobulin like receptor three domains , short cytoplasmic tail, 1;Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1;KIR antigen 3DL1;KIR G1;KIR3DS1;Kirl1;Kirl2;Krl1;MGC119726;MGC119728;MGC126589;MGC126591;MHC class I NK cell receptor;Natural killer associated transcript 3;Natural killer cell inhibitory receptor;NK receptor;NK-associated transcript 10;NK-associated transcript 3;NK-associated transcript 3delIg1;NKAT10;p70 killer cell inhibitory receptor;p70 natural killer cell receptor clones CL 2/CL 11;NKAT-3;NK-receptor;OTTHUMP00000068687;OTTHUMP00000068688;OTTHUMP00000081758;killer Ig receptor;p70 NK receptor CL-2/CL-11;p70 ki;KIR3DL1/S1
Recombinant Proteins
- Rat
- Human
- Mus musculus
- Mammalian Cells
- E.coli
- Human
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
KIR3DL1 involved in several pathways and played different roles in them. We selected most pathways KIR3DL1 participated on our site, such as Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR3DL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | H2-Q10,KIR2DL3,TNF,KLRC3,H2-AB1,H2-AA,CD8B,HSPA5,TAPBP,HLA-DRB3 |
| Graft-versus-host disease | KIR2DL1,HLA-E,CD80,CD28,HLA-G,HLA-DMA,HLA-DQA1,TNF,CD86,IFNG |
| Natural killer cell mediated cytotoxicity | NCR1,RAET1L,BID,NFATC1,KLRD1,KIR2DS2,KIR3DL2,PPP3CB,TNFRSF10D,IFNA14 |
Protein Function
KIR3DL1 has several biochemical functions, for example, HLA-B specific inhibitory MHC class I receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR3DL1 itself. We selected most functions KIR3DL1 had, and list some proteins which have the same functions with KIR3DL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| HLA-B specific inhibitory MHC class I receptor activity | LILRB1 |
Interacting Protein
KIR3DL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR3DL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR3DL1.
RPS6KB1;env
Resources
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References
- Gooneratne, SL; Richard, J; et al. Slaying the Trojan Horse: Natural Killer Cells Exhibit Robust Anti-HIV-1 Antibody-Dependent Activation and Cytolysis against Allogeneic T Cells. JOURNAL OF VIROLOGY 89:97-109(2015).
- de Rham, C; Hadaya, K; et al. Expression of killer cell immunoglobulin-like receptors (KIRs) by natural killer cells during acute CMV infection after kidney transplantation. TRANSPLANT IMMUNOLOGY 31:157-164(2014).
