JAK3
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Official Full Name
Janus kinase 3 -
Overview
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a -
Synonyms
JAK3;Janus kinase 3;tyrosine-protein kinase JAK3;JAK 3;JAK3_HUMAN;JAKL;L JAK;leukocyte Janus kinase;LJAK;tyrosine protein kinase JAK3;Janus kinase 3 (a protein tyrosine kinase, leukocyte);JAK-3;L-JAK
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Insect Cell
- S.frugiperda
- HEK293
- Sf9 Insect Cell
- Mammalian Cell
- Human cells
- Yeast
- Mamanlian cells
- HEK293T
- Insect cells
- His
- GST
- His&GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
JAK3 involved in several pathways and played different roles in them. We selected most pathways JAK3 participated on our site, such as ARMS-mediated activation,Axon guidance,CD40/CD40L signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | SHB,EFNA1,AP2B1,CLTA,EPHB4B,TRPC7,NRG2A,CNKSR1,ADAM23,RGMB |
| Cytokine Signaling in Immune system | TRIM3,KBTBD7,SPTBN2,DUSP7,ADAR,PEA15,TRIM22,PTPRA,TRIM2,SPRED1 |
| ARMS-mediated activation | PEA15A,DUSP9,NEFLB,DLG4,KIDINS220B,DUSP10,RASGEF1A,MARK3,PSMD5,DUSP6 |
| DAP12 signaling | DUSP9,NRG2A,CSF2RA,PTPRA,AGO1,DUSP5,RASGEF1A,DUSP2,AGO3,SPTA1 |
| Chemokine signaling pathway | CCL7,XCL2,NRAS,LOC100033925,PLCB1,CCL14,MAP2K1,GRK7,PRKACB,MAPK1 |
| CD40/CD40L signaling | TDP2,MYC |
| DAP12 interactions | IL17RD,KIR2DS2,DUSP9,FRS2A,KBTBD7,SPTA1,CSF2RB,SIGLEC15,RASGEF1A,PEA15 |
| Axon guidance | ABLIM1,FRS2A,ACTR2B,EPHA10,PLXNA1,CHL1,NRP1A,EPHB1,SLIT2,NTN1 |
Protein Function
JAK3 has several biochemical functions, for example, ATP binding,hormone receptor binding,non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK3 itself. We selected most functions JAK3 had, and list some proteins which have the same functions with JAK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| non-membrane spanning protein tyrosine kinase activity | FER,YES1,PRKCD,TNK1,BMX,SYK,CLK1,TXK,ZNF143B,PTK6 |
| protein binding | TCEAL5,GRB2,C21orf2,EDNRB,PCBP2,FCER1G,WASF1,PELI3,GAPDH,ZNF79 |
| hormone receptor binding | TNK2B,TNK2,JAK2B,SRC,JAK2A,TNK1 |
| protein phosphatase binding | DRD1A,ANAPC4,DLG3,DRD1,VCAN,TRP53,EIF2AK3,VCP,ITPR1,ERBB2 |
| protein tyrosine kinase activity | EPHB4B,JAK2A,DYRK1B,PTK7,EPHB2B,SRC,NTRK2B,WEE2,BLK,WEE1 |
| ATP binding | RECQL5,ATAD5B,ROR1,NDUFA13,MYH6,TAOK3,DHX33,DHX32A,PI4KA,PIK3C2G |
Interacting Protein
JAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK3.
TCP1;CCT6A;CCT8;CCT4;NAP1L1;MAGED2;LNX1;saicar;NFATC1;PKM;ERBB3
JAK3 Related Signal Pathway
Resources
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References
- Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).
- Bauer, SM; Gehringer, M; et al. A direct enzyme-linked immunosorbent assay (ELISA) for the quantitative evaluation of Janus Kinase 3 (JAK3) inhibitors. ANALYTICAL METHODS 6:8817-8822(2014).
