IRF3
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Official Full Name
interferon regulatory factor 3 -
Overview
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] -
Synonyms
IRF3;interferon regulatory factor 3
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- SUMO
- Avi
- Fc
- Myc
- DDK
- Flag
- GST
Involved Pathway
IRF3 involved in several pathways and played different roles in them. We selected most pathways IRF3 participated on our site, such as Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Measles | IL2RB,TRP53,PIK3R5,PIK3R1,CD209A,CCND3,PRKCQ,IKBKE,IFNA10,Ifna15 |
| Influenza A | TNFSF10,MAP2K4,BCL2L2-PABPN1,IKBKB,Ifna15,BMA1,MAPK3,ICAM1,FURIN,IFNAR2 |
| RIG-I-like receptor signaling pathway | IKBKG,IFNA12,PL10,IFNB,NFKBIAA,TP-1,CASP8,IL8L2,TBK1,IRF7 |
| Herpes simplex infection | HNRPKL,SRSF9,SP100,HLA-DOA,SFRS9,IL15,MAPK8B,IFNA16,IL12A,HMGN1 |
| Hepatitis B | IFNB1,NFKBIA,MAP2K4,IFN-a,MAPK8,NFATC3,PIK3CG,SMAD3,RAF1,GRB2 |
| Hepatitis C | NR1H3,IFNA12,MAPK12,RAF1,AKT2,PIK3CA,PIK3CD,HRAS,MAPK9,CLDN15 |
| Pertussis | NFKB1,CASP1,ITGAM,C4A,C1S,MYD88,PYCARD,IL1B,IL23,C3 |
| Cytosolic DNA-sensing pathway | RIPK1L,CCL4L1,NFKBIA,TBK1,IKBKE,IL18,IFNA2,POLR2L,POLR2H,RELA |
| Epstein-Barr virus infection | HLA-DRA,PIK3R3,AKT1,TBK1,POLR3H,HLA-F,Fcer2a,TRAF6,SYK,AKT2 |
Protein Function
IRF3 has several biochemical functions, for example, DNA binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF3 itself. We selected most functions IRF3 had, and list some proteins which have the same functions with IRF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PARP16,STUB1,CENPK,XRCC1,ARNT,C19orf47,LAMTOR3,SEPT11,PPP6R2,NOTCH3 |
| identical protein binding | G6PD,CBS,SERPINA1D,ATF3,GRIN3A,MAPK1IP1,CBLL1,WAS,HAND1,NQO1 |
| DNA binding | PML,H2AFY,ISL1L,LBX1,HOXD13A,NR4A2,POU2F1B,TRIM26,TCEA3,EPAS1 |
| protein homodimerization activity | BAX,BCL2A1A,AGXT,HPS4,RNF17,AOC3,RAB11FIP4A,USH2A,SYNDIG1,MTHFD1L |
| transcription factor activity, sequence-specific DNA binding | NR1D4B,ZNF238,CBFA2T3,PTTG1,REST,TEAD2,BLZF1,AHRRB,ZFP191,TRP63 |
| regulatory region DNA binding | IRF5,IRF2A,IRF8,IRF4A,IRF1B,IRF1A,HMGA2,NFKB1,IRF6 |
| transcription cofactor activity | LDB2,POU2AF1,MED16,CREB1,FAM48A,ZNF710A,MED13,ZNF710,KAT2B,TAF13 |
Interacting Protein
IRF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF3.
TBK1;CREBBP
Resources
Research Area
Transcription Regulators in VSMCTranscription Factors in the Akt Pathway
Inflammatory Bowel Diseases Therapeutic Targets
RIG-I-like Receptors
Related Services
Related Products
References
- Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).
- Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).
