IRF3

  • Official Full Name

    interferon regulatory factor 3
  • Overview

    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
  • Synonyms

    IRF3;interferon regulatory factor 3

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • Yeast
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • T7
  • Non
  • SUMO
  • Avi
  • Fc
  • Myc
  • DDK
  • Flag
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
IRF3-61H Recombinant Human IRF3 protein, His/T7-tagged E.coli Human His&T7 Met1~Lys360
IRF3-2297R Recombinant Rhesus monkey IRF3 Protein, His-tagged Mammalian Cells Rhesus macaque His
IRF3-27H Recombinant Human Interferon Regulatory Factor 3 E.coli Human Non 1-112 a.a.
IRF3-60H Recombinant Human IRF3 protein, His-tagged E.coli Human His 442aa(including fusion tag)
IRF3-62H Recombinant Human IRF3 protein, His/sumo-tagged E.coli Human His&SUMO 1-452 aa
Irf3-7149M Recombinant Mouse Irf3 protein, His & T7-tagged E.coli Mouse His&T7 Met1~Asp406
IRF3-7262Z Recombinant Zebrafish IRF3 Mammalian Cells Zebrafish His
IRF3-8301M Recombinant Mouse IRF3 Protein Mammalian Cells Mouse His
IRF3-5166HCL Recombinant Human IRF3 293 Cell Lysate HEK293 Human Non
IRF3-013H Recombinant Human IRF3 Protein, His-tagged E.coli Human His 1-427
IRF3-072H Recombinant Human IRF3 Protein, His-tagged E.coli Human His 1-427
IRF3-1196H Recombinant Human IRF3 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IRF3-1196H-B Recombinant Human IRF3 Protein Pre-coupled Magnetic Beads HEK293 Human
IRF3-2118R Recombinant Rhesus Macaque IRF3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IRF3-2118R-B Recombinant Rhesus Macaque IRF3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IRF3-2146M Recombinant Mouse IRF3 Protein (1-419 aa), His-Myc-tagged Yeast Mouse His&Myc 1-419 aa
IRF3-2892H Recombinant Human IRF3 Protein (Met1-Ser123), N-His tagged E.coli Human His Met1-Ser123
Irf3-3115M Recombinant Mouse Irf3 protein, His&Myc-tagged E.coli Mouse His&Myc 1-419aa
Irf3-3574M Recombinant Mouse Irf3 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
IRF3-4151H Recombinant Human IRF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IRF3-4603M Recombinant Mouse IRF3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IRF3-4603M-B Recombinant Mouse IRF3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IRF3-497HFL Recombinant Full Length Human IRF3 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
IRF3-5041H Recombinant Human IRF3 Protein, GST-tagged Wheat Germ Human GST
IRF3-5738HF Recombinant Full Length Human IRF3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 452 amino acids

    Involved Pathway

    IRF3 involved in several pathways and played different roles in them. We selected most pathways IRF3 participated on our site, such as Toll-like receptor signaling pathway,RIG-I-like receptor signaling pathway,Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytosolic DNA-sensing pathway IFNA3,IL6,CCL4L2,IL1B,POLR2H,IFNA8,IFNA10,NFKBIAB,TREX1,IFNB1
    Toll-like receptor signaling pathway Ifna15,MAP2K1,AKT2,IFNPHI3,FADD,IKBKB,MAPK14B,IFNA4,TLR4,IFNA2
    RIG-I-like receptor signaling pathway IRF7,MAPK11,IFNA1,RIPK1,ISG15,IFNA14,TRAF3,IFNA6,CASP10,TP-1
    Hepatitis C NFKBIA,IKBKB,IFNA1,IFNA8,PPP2R2D,EIF2AK4,CLDN18,IFNA16,EIF2AK1,RAF1
    Herpes simplex infection TRAF1,IRF9,PPP1CA,PILRA,IFNA4,SRSF7,OAS1B,HLA-DRB5,IFNGR1,Casp3
    Pertussis C5,Il23a,IL12A,C3,C1RA,IRAK1,CXCL6,C4BP,TLR4,GNAI3
    Hepatitis B OSTN,MAPK9,CASP12,STAT3,ATF4,TP53,MAP3K1,STAT6,CREB3L3,IL-8
    Influenza A BLB1,MAP2K1,IL6,IFNA14,TLR7,IFNGR2,TNFRSF10A,IL8L2,NFKBIA,MAP2K4
    Viral carcinogenesis CREB3L3,RHOA,HLA-C,ATP6V0D1,KRAS,HIST1H2BA,NFKB2,HLA-E,HIST1H4I,TBPL1

    Protein Function

    IRF3 has several biochemical functions, for example, DNA binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF3 itself. We selected most functions IRF3 had, and list some proteins which have the same functions with IRF3. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding TFEB,ATF7,EVX1,DRAP1,HOXC6A,SOX3,E2F7,PAX7,TBX24,TCF3A
    protein binding SULT2B1,UBE3A,OBFC1,TECPR2,STAT3,FBXL8,SNRPB2,TUBB,CRIPT,DPP4
    regulatory region DNA binding IRF4A,IRF1B,IRF1A,NFKB1,IRF8,IRF2A,IRF5,IRF6,HMGA2
    transcription cofactor activity PIR,MED13,HES6,ZFP710,ZNF671,MAP3K7,BTG1,MED1,TFB2M,LDB2A
    protein homodimerization activity MVD,HPRT1,GSS,TPD52,LHPP,CR2,HOGA1,S100A5,TFRC,TGFB1
    DNA binding HOXB1A,ZNF227,ZFP35,FOXL1,MCM9,OLIG1,C1D,SOX3,TRIM16,AHDC1
    identical protein binding DES,P2RX6,IGF2R,SFRP1,RELA,AGER,CLPP,MAPK1IP1,NELL2,BCL2L1

    Interacting Protein

    IRF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF3.

    TBK1;CREBBP

    Resources

    Gene Families

    Cytokines

    References

    • Wang, J; Vodovotz, Y; et al. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. FASEB JOURNAL 29:250-262(2015).
    • Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).

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