Ifnar1

  • Official Full Name

    interferon (alpha, beta and omega) receptor 1

  • Overview

    The antibody when prepared specifically for In vivo functional assays blocks type I IFN receptor signaling both In vitro and In vivo without depleting IFNAR1 bearing cells. This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.

  • Synonyms

    IFNAR1;interferon (alpha, beta and omega) receptor 1;IFNAR;interferon alpha/beta receptor 1;IFRC;CRF2-1;IFN-R-1;IFN-alpha/beta receptor 1;interferon-beta receptor 1;beta-type antiviral protein;alpha-type antiviral protein;type I interferon rece;AVP;RF2-1;cytokine receptor class-II member 1;cytokine receptor family 2 member 1;human interferon-alpha receptor (HuIFN-alpha-Rec);IFN-alpha-REC;IFNBR;interferon-alpha/beta receptor alpha chain;nterferon-beta receptor 1;TTHUMP00000067672;FRC;type I interferon receptor 1

Recombinant Proteins

  • Mouse
  • Human
  • Cynomolgus
  • Rhesus macaque
  • Chicken
  • Rat
  • Mus musculus
  • HEK293
  • E.coli
  • C-His
  • Wheat Germ
  • Mammalian Cells
  • Human Cells
  • Myeloma cells
  • In Vitro Cell Free System
  • His
  • Fc
  • Non
  • Avi&His
  • LEVLFQ
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
Ifnar1-3360M Active Recombinant Mouse Ifnar1 protein, His-tagged HEK293 Mouse His 1-429 a.a.
IFNAR1-3262H Recombinant Human IFNAR1 protein, His-tagged E.coli Human His
IFNAR1-1407C Recombinant Cynomolgus IFNAR1 protein, His-tagged C-His Cynomolgus Ala25-Lys437
IFNAR1-188H Recombinant Human IFNAR1 protein, Fc-tagged HEK293 Human Fc Lys28-Lys436
IFNAR1-2205R Recombinant Rhesus IFNAR1 Protein, His-tagged HEK293 Rhesus macaque His Met1-Lys436
IFNAR1-28344TH Recombinant Human IFNAR1 Wheat Germ Human Non 557 amino acids
IFNAR1-29420TH Recombinant Human IFNAR1 Wheat Germ Human Non 100 amino acids
IFNAR1-508H Recombinant Human IFNAR1 Protein, Fc-tagged HEK293 Human Fc 1-436 a.a.
IFNAR1-509H Recombinant Human IFNAR1 protein, His-tagged HEK293 Human His Met1-Lys436
IFNAR1-6422C Recombinant Chicken IFNAR1 Mammalian Cells Chicken His
IFNAR1-6938H Recombinant Human IFNAR1 protein, His-tagged E.coli Human His Leu25~Ser146
Ifnar1-6939M Recombinant Mouse Ifnar1 protein, His-tagged E.coli Mouse His Arg104~Thr341
Ifnar1-6940R Recombinant Rat Ifnar1 protein, His-tagged E.coli Rat His Val90~Arg358
IFNAR1-78C Recombinant Cynomolgus IFNAR1, Fc tagged Human Cells Cynomolgus His 1-437 a.a.
IFNAR1-80C Recombinant Cynomolgus IFNAR1, LEVLFQ tagged Human Cells Cynomolgus His 1-437 a.a.
IFNAR1-946H Recombinant Human IFNAR1 Protein, His-tagged HEK293 Human His
IFNAR1-1643HCL Recombinant Human IFNAR1 cell lysate Human Cells Human Non
IFNAR1-2372MCL Recombinant Mouse IFNAR1 cell lysate Human Cells Mouse Non
IFNAR1-816CCL Recombinant Cynomolgus IFNAR1 cell lysate Human Cells Cynomolgus Non
IFNAR1-001H Recombinant Human IFNAR1 Protein Mammalian Cells Human Non
IFNAR1-096R Recombinant Rhesus IFNAR1 protein, hFc-tagged HEK293 Rhesus macaque Fc Met1-Lys437
IFNAR1-1175R Recombinant Rhesus IFNAR1 protein(Met1-Lys437) HEK293 Rhesus macaque Non Met1-Lys437
IFNAR1-11H Active Recombinant Human IFNAR1 Protein Myeloma cells Human 26-436 a.a.
IFNAR1-181H Recombinant Human IFNAR1 protein, His-Avi-tagged HEK293 Human Avi&His Lys28-Lys436
IFNAR1-181HB Recombinant Human IFNAR1 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Lys28-Lys436
IFNAR1-2206R Recombinant Rhesus IFNAR1 Protein, LEVLFQ-tagged HEK293 Rhesus macaque LEVLFQ Met1-Lys437
IFNAR1-2509H Recombinant Human IFNAR1 Protein (Lys28-Lys436), C-His tagged Mammalian Cells Human His Lys28-Lys436
IFNAR1-250HF Recombinant Full Length Human IFNAR1 Protein In Vitro Cell Free System Human Full L. 557 amino acids
IFNAR1-2510H Recombinant Human IFNAR1 Protein (Lys28-Asn227), N-His tagged E.coli Human His Lys28-Asn227
IFNAR1-294H Recombinant Human IFNAR1 Protein, Fc-tagged HEK293 Human Fc 557
IFNAR1-3263H Recombinant Human IFNAR1 protein(458-557 aa), His-tagged E.coli Human His 458-557 aa
IFNAR1-4251H Recombinant Human IFNAR1 Protein (Met1-Lys436), C-His tagged Mammalian Cells Human His Met1-Lys436
IFNAR1-4424H Recombinant Human IFNAR1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IFNAR1-4424H-B Recombinant Human IFNAR1 Protein Pre-coupled Magnetic Beads HEK293 Human
IFNAR1-P004H Recombinant Human IFNAR1 therapeutic protein(Peginterferon alfa-2a) E.coli Human Non 165aa
RFL14339MF Recombinant Full Length Mouse Interferon Alpha/Beta Receptor 1(Ifnar1) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (27-590)
RFL23097HF Recombinant Full Length Human Interferon Alpha/Beta Receptor 1(Ifnar1) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (28-557)

    Involved Pathway

    Ifnar1 involved in several pathways and played different roles in them. We selected most pathways Ifnar1 participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifnar1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hepatitis B NFATC4,SMAD4,MAP2K2,MYD88,NFATC2,PIK3CG,PIK3CB,TGFB3,BAD,TRP53
    Hepatitis C IRF1,CLDN7,STAT2,PIK3CB,IFNA17,CLDN18,SCARB1,IFNA13,IFNA12,CLDN8
    PIK-Akt signaling pathway Itga10&Itgb1,Gh,YWHAB,PRLR,LAMA4,GNB3,EPOR,MTCP1,LAMA2,CD19
    Influenza A NXT1,IFNA7,IRAK4,SLC25A6,NXF1,EIF2AK1,NFKBIA,DDX58,HLA-DRB1,IFNA6
    Toll-like receptor signaling pathway TLR9,TLR1LB,IFNA16,IFNA21,IKBKB,NFKBIAB,IFNPHI1,PIK3CB,MAPK14A,PIK3R3B
    Jak-STAT signaling pathway HRAS,GFAP,CNTFR,SOS1,BCL2L1,Ifna15,IL9R,IFNA14,IL29,PRL
    Measles Fasl,IFNGR2,MX1,PIK3CA,IFNB1,CCND1,TNFSF10,Ifna15,CCNE1,TNFRSF10A
    Natural killer cell mediated cytotoxicity HLA-B,MAP2K2,TNFRSF10D,RAET1E,IFNA14,SHC4,Ifna15,IFNA6,KLRA8,PPP3R1
    Herpes simplex infection EP300,JAK2B,TAF5L,LOC100033925,OAS1,DDX58,OAS2,PILRA,ARNTL,HLA-DRA

    Protein Function

    Ifnar1 has several biochemical functions, for example, protein binding,type I interferon receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifnar1 itself. We selected most functions Ifnar1 had, and list some proteins which have the same functions with Ifnar1. You can find most of the proteins on our site.

    Function Related Protein
    type I interferon receptor activity IFNAR2
    protein binding TPI1,XPO6,MAP3K3,NINJ1,NQO1,COLQ,FBXL3,CCDC121,SCRN1,SYCE3

    Interacting Protein

    Ifnar1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifnar1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifnar1.

    STAT2;FBXW11;IFNW1;TYK2;IFNAR2;EP300;q86up4_human;glpK

    Ifnar1 Related Signal Pathway

    Resources

    Gene Families

    Cytokines

    Research Area

    Interferon receptor
    IL-10 Family Receptors

    References

    • Badr, BM; Moustafa, NA; et al. Increased Levels of Type 1 Interferon in a Type 1 Diabetic Mouse Model Induce the Elimination of B Cells from the Periphery by Apoptosis and Increase their Retention in the Spleen. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:137-147(2015).
    • Kuruganti, S; Accavitti-Loper, MA; et al. Production and characterization of thirteen human type-I interferon-alpha Mark subtypes. PROTEIN EXPRESSION AND PURIFICATION 103:75-83(2014).

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