HSD17B14
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 14 -
Overview
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17;position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007;(PubMed 17067289)). -
Synonyms
HSD17B14;hydroxysteroid (17-beta) dehydrogenase 14;dehydrogenase/reductase (SDR family) member 10 , DHRS10;17-beta-hydroxysteroid dehydrogenase 14;retinal short chain dehydrogenase/reductase 3;retSDR3;SDR47C1;short chain dehydrogenase/reductase family 47C;member 1;17 beta hydroxysteroid dehydrogenase 14;17 beta hydroxysteroid dehydrogenase DHRS10;Dehydrogenase/reductase SDR family member 10;DHRS10;Retinal short chain dehydrogenase/reductase retSDR3;SDR3;17-beta-HSD 14;17-beta-hydroxysteroid dehydrogenase DHRS10;retinal short-chain dehydrogenase/reductase 3;dehydrogenase/reductase (SDR family) member 10;retinal short-chain dehydrogenase/reductase retSDR3;short chain dehydrogenase/reductase family 47C, member 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cell
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
- Flag
Involved Pathway
HSD17B14 involved in several pathways and played different roles in them. We selected most pathways HSD17B14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HSD17B14 has several biochemical functions, for example, estradiol 17-beta-dehydrogenase activity,protein binding,testosterone 17-beta-dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B14 itself. We selected most functions HSD17B14 had, and list some proteins which have the same functions with HSD17B14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| estradiol 17-beta-dehydrogenase activity | HSD17B2,HSD17B6,AKR1B15,RDH8B,HSD17B10,H2-KE6,HSD17B8,HSD17B11,HSD17B12A,AKR1C6 |
| protein binding | MPZL1,FAM104A,TTBK2,CDKN2C,YEATS4,ASB13,CYFIP1,MUL1,DNM3,SIX5 |
| testosterone 17-beta-dehydrogenase (NADP+) activity | AKR1C3,HSD17B3,AKR1C6 |
Interacting Protein
HSD17B14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B14 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B14.
WDYHV1;NUDT18;PHF1;MPG;CA8;DDIT3
Resources
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References
- Sivik, T; Vikingsson, S; et al. Expression Patterns of 17 beta-Hydroxysteroid Dehydrogenase 14 in Human Tissues. HORMONE AND METABOLIC RESEARCH 44:949-956(2012).
- Sivik, T; Gunnarsson, C; et al. 17 beta-Hydroxysteroid Dehydrogenase Type 14 Is a Predictive Marker for Tamoxifen Response in Oestrogen Receptor Positive Breast Cancer. PLOS ONE 7:-(2012).
