HPSE
- Product List
- Overview
- Review / Q&A
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Official Full Name
heparanase -
Overview
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] -
Synonyms
HPSE;heparanase;HPA;HPA1;HPR1;HSE1;HPSE1;heparanase-1;endo-glucoronidase
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- CHO
- Mammalian Cells
- E.coli
- Wheat Germ
- Myeloma
- HEK293
- Non
- His
- GST
- T7
- Avi
- Fc
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HPSE-213H |
Recombinant Human Heparanase
|
CHO | Human | Non | ||
| HPSE-156H |
Active Recombinant Human HPSE, His-tagged
|
CHO | Human | His |
|
|
| HPSE-431H |
Active Recombinant Human HPSE protein, His-tagged
|
CHO | Human | His | 36-543;110-157 a.a. |
|
| HPSE-2907R | Recombinant Rat HPSE Protein | Mammalian Cells | Rat | His |
|
|
| HPSE-4085Z | Recombinant Zebrafish HPSE | Mammalian Cells | Zebrafish | His |
|
|
| HPSE-467H | Recombinant Human heparanase, His-tagged | E.coli | Human | His | 36-543 a.a. |
|
| HPSE-5019H | Recombinant Human HPSE Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| HPSE-5068H | Recombinant Human HPSE, His-tagged | E.coli | Human | His |
|
|
| HPSE-5742C | Recombinant Chicken HPSE | Mammalian Cells | Chicken | His |
|
|
| Hpse-703M | Recombinant Mouse Hpse protein, His-tagged | E.coli | Mouse | His | Thr27~Glu101 |
|
| Hpse-704M | Recombinant Mouse Hpse protein, His-tagged | E.coli | Mouse | His | Glu280~Leu412 |
|
| Hpse-705M | Recombinant Mouse Hpse protein, His-tagged | E.coli | Mouse | His | Asp419~Ile535 |
|
| Hpse-706M | Recombinant Mouse Hpse protein, His-tagged | E.coli | Mouse | His | Ala353~Arg464 |
|
| Hpse-707R | Recombinant Rat Hpse protein, His & T7-tagged | E.coli | Rat | His&T7 | Arg40~Pro188 |
|
| HPSE-7838M | Active Recombinant Mouse HPSE Protein, His-tagged | Myeloma | Mouse | His | 28-535 |
|
| HPSE-2251H | Recombinant Human HPSE Protein, His-tagged | E.coli | Human | His | Pro400-Ile543 |
|
| HPSE-2252H | Recombinant Human HPSE Protein, His-tagged | E.coli | Human | His | Leu151-Ile543 |
|
| HPSE-2562R | Recombinant Rat HPSE Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
|
|
| Hpse-3051R | Recombinant Rat Hpse protein, His&Myc-tagged | E.coli | Rat | His&Myc | 29-102aa |
|
| HPSE-3443H | Recombinant Human HPSE Protein (Gln34-Arg115), N-His tagged | E.coli | Human | His | Gln34-Arg115 |
|
Involved Pathway
HPSE involved in several pathways and played different roles in them. We selected most pathways HPSE participated on our site, such as Glycosaminoglycan degradation,Glycosaminoglycan metabolism,HS-GAG degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPSE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | WNT8B,RPS6KB2,WNT8A,PIK3R3,PIK3CA,MMP2,SLC9A1,BRAF,ITGB1,GRB2 |
| Glycosaminoglycan degradation | GNS,IDUA,HEXA,IDS,SPAM1,HYAL3,HYAL4,HGSNAT,HYAL2,GALNS |
| Metabolism of carbohydrates | SLC26A2,SLC25A11,OXSR1,Gpc2,OMD,SLC5A9,SLC35B2,SLC35B3,SLC35D2,STAB2 |
| Metabolic pathways | PLA2G4AA,NMRK2,UGT2A3,ACSS3,COX6C,PCK1,CYP3A5,NT5C1BA,TUSC3,CBR1 |
| Metabolism | TM9SF1,TYMP,OMD,OAZ3,Gpc2,GGTLC1,CERS4A,NDOR1,NFYBA,ARF3 |
| HS-GAG degradation | GPC1A,Gpc2,GPC5A,GLB1L,GPC1B |
| Glycosaminoglycan metabolism | B3GNT1,LYVE1,MAPK1IP1L,SLC35B2,CHST14,OGN,SLC26A1,GLB1L,GPC1B,B3GAT2 |
| Heparan sulfate/heparin (HS-GAG) metabolism | B4GALT7,HS3ST4,MAPK1IP1L,B3GAT2,HS3ST6,CSPG5B,GPC5A,GPC1A,SLC35D2,GLB1L |
Protein Function
HPSE has several biochemical functions, for example, beta-glucuronidase activity,heparanase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPSE itself. We selected most functions HPSE had, and list some proteins which have the same functions with HPSE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| syndecan binding | TNC,SDCBP,CHRD,SEMA5A |
| protein binding | TXNDC9,TIMELESS,RUVBL1,IRF8,RPL5,RILP,FGFRL1A,ZNF274,SZL,TATDN1 |
| beta-glucuronidase activity | GUSB |
| protein dimerization activity | MYCS,TCF3B,EBF3A,HER6,ID4,HES2.2,WWOX,AHR,TWIST1A,SIM1A |
Interacting Protein
HPSE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPSE here. Most of them are supplied by our site. Hope this information will be useful for your research of HPSE.
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References
- Zhang, J; Yang, JM; et al. Multiple antigenic polypeptide composed of heparanase B-cell epitopes shrinks human hepatocellular carcinoma in mice. ONCOLOGY REPORTS 33:1248-1256(2015).
- Zhang, J; Yang, JM; et al. Synthesized Multiple Antigenic Polypeptide Vaccine Based on B-Cell Epitopes of Human Heparanase Could Elicit a Potent Antimetastatic Effect on Human Hepatocellular Carcinoma In Vivo. PLOS ONE 8:-(2013).
