HPRT1
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Official Full Name
hypoxanthine phosphoribosyltransferase 1 -
Overview
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate;and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl;1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage;pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout. -
Synonyms
HPRT1;hypoxanthine phosphoribosyltransferase 1;HPRT;hypoxanthine-guanine phosphoribosyltransferase;HGPRT;Lesch Nyhan syndrome;HGPRTase;HPRT 1;HPRT_HUMAN;Hypoxanthine guanine phosphoribosyltransferase;Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Cynomolgus
- Chicken
- Mouse
- Mammalian Cell
- Human
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E. coli
- Mammalian cells
- His
- GST
- Non
- His&Strep
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HPRT1-12230Z | Recombinant Zebrafish HPRT1 | Mammalian Cell | Zebrafish | His |
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| HPRT1-1796H | Recombinant Human Hypoxanthine Phosphoribosyltransferase 1, His-tagged | Human | Human | His |
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| HPRT1-28755TH | Recombinant Human HPRT1, His-tagged | E.coli | Human | His | 218 amino acids |
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| HPRT1-2905R | Recombinant Rat HPRT1 Protein | Mammalian Cell | Rat | His |
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| HPRT1-5011H | Recombinant Human HPRT1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HPRT1-595C | Recombinant Cynomolgus HPRT1 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| HPRT1-6411C | Recombinant Chicken HPRT1 | Mammalian Cell | Chicken | His |
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| HPRT1-5398HCL | Recombinant Human HPRT1 293 Cell Lysate | HEK293 | Human | Non |
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| HPRT1-0321H | Recombinant Human HPRT1 Protein (M1-A218), Tag Free | E.coli | Human | Non | M1-A218 |
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| HPRT1-0322H | Recombinant Human HPRT1 Protein (M1-A218), His/Strep tagged | E.coli | Human | His&Strep | M1-A218 |
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| HPRT1-1096H | Recombinant Human HPRT1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| HPRT1-1096H-B | Recombinant Human HPRT1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| HPRT1-2145H | Recombinant Human HPRT1 protein | E.coli | Human | Non | 2-218aa |
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| HPRT1-2357H | Recombinant Human HPRT1 Protein (Met1-Ala218), N-His tagged | E.coli | Human | His | Met1-Ala218 |
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| HPRT1-2358H | Recombinant Human HPRT1 Protein (Thr3-Ala218), N-GST tagged | E.coli | Human | GST | Thr3-Ala218 |
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| HPRT1-2560R | Recombinant Rat HPRT1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HPRT1-2560R-B | Recombinant Rat HPRT1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| HPRT1-2696M | Recombinant Mouse HPRT1 Protein, GST-tagged | E.coli | Mouse | GST | Thr3-Ala218 |
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| HPRT1-2889H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHLSTAADMQGVVTDGMASGLDKDYLKPDDGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-2890H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKWFKIQMQIRRWKNKRGLFDIIKKIAESFGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-2891H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKETWWETWWTEWSQPKKKRKVWEAALAEALAEALAEHLAEALAEALEALAAGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-2892H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKETWWETWWTEWSQPKKKRKVGIGEVLHELADDLPELQSWIKAAQQLGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-2893H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKETWWETWWTEWSQPKKKRKVAEEQQPWAQYLELLFPTETLLLEWGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-2894H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHLSTAADMQGVVTDGMASGLDKDYLKPDDGLFDIIKKIAESFGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-2895H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHGALFLAFLAAALSLMGLWSQPKKKRKVGIGEVLHELADDLPELQSWIKAAQQLGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-2896H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHGALFLAFLAAALSLMGLWSQPKKKRKVAEEQQPWAQYLELLFPTETLLLEWGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-341C | Recombinant Cynomolgus Monkey HPRT1 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| HPRT1-341C-B | Recombinant Cynomolgus Monkey HPRT1 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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| HPRT1-3434H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHHHHHGALFLAFLAAALSLMGLWSQPKKKRKVWEAALAEALAEALAEHLAEALAEALEALAAGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-3435H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHHHHHYGRKKRRQRRRGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-3628HF | Recombinant Full Length Human HPRT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 218 amino acids |
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| HPRT1-4769H | Recombinant Human HPRT1 protein, His-tagged | E. coli | Human | His | 233aa(including fusion tag) |
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| HPRT1-5112H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHRQIKIWFQNRRMKWKKGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5113H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHGWTLNSAGYLLGKINLKALAALAKKILGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5114H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKETWWETWWTEWSQPKKKRKVGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5115H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHYGRKKRRQRRRWEAALAEALAEALAEHLAEALAEALEALAAGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5116H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHYGRKKRRQRRRGLFDIIKKIAESFGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5117H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHYGRKKRRQRRRGIGEVLHELADDLPELQSWIKAAQQLGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5118H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHYGRKKRRQRRRAEEQQPWAQYLELLFPTETLLLEWGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5119H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHRQIKIWFQNRRMKWKKWEAALAEALAEALAEHLAEALAEALEALAAGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5120H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHRQIKIWFQNRRMKWKKGLFGAIAGFIEGGWTGMIDGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5121H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHRQIKIWFQNRRMKWKKGLFDIIKKIAESFGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5122H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHRQIKIWFQNRRMKWKKGIGEVLHELADDLPELQSWIKAAQQLGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5123H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHRQIKIWFQNRRMKWKKAEEQQPWAQYLELLFPTETLLLEWGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5124H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKWFKIQMQIRRWKNKRWEAALAEALAEALAEHLAEALAEALEALAAGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5125H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKWFKIQMQIRRWKNKRGIGEVLHELADDLPELQSWIKAAQQLGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5126H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKWFKIQMQIRRWKNKRAEEQQPWAQYLELLFPTETLLLEWGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5127H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHGWTLNSAGYLLGKINLKALAALAKKILWEAALAEALAEALAEHLAEALAEALEALAAGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5128H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKETWWETWWTEWSQPKKKRKVGLFGAIAGFIEGGWTGMIDGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5129H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKETWWETWWTEWSQPKKKRKVGLFDIIKKIAESFGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5130H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHLSTAADMQGVVTDGMASGLDKDYLKPDDWEAALAEALAEALAEHLAEALAEALEALAAGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-5298H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | 2-218aa |
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| HPRT1-5322H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHKWFKIQMQIRRWKNKRGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-619HFL | Recombinant Full Length Human HPRT1 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| HPRT1-948H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHHHHHKWFKIQMQIRRWKNKRGLFGAIAGFIEGGWTGMIDGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-949H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHGWTLNSAGYLLGKINLKALAALAKKILAEEQQPWAQYLELLFPTETLLLEWGGGGGSGFLGPAPAPAPAPA+2-218aa |
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| HPRT1-950H | Recombinant Human HPRT1 protein, His-tagged | E.coli | Human | His | MHHHHHHLSTAADMQGVVTDGMASGLDKDYLKPDDGIGEVLHELADDLPELQSWIKAAQQLGGGGSGFLGPAPAPAPAPA+2-218aa |
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Involved Pathway
HPRT1 involved in several pathways and played different roles in them. We selected most pathways HPRT1 participated on our site, such as Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | ZNRD1,PGM2,PDE2A,NT5C1BA,NME3,URAH,FHIT,PDE8A,POLR2B,AK5 |
| Drug metabolism - other enzymes | UGT2B7,UGT2A1,Ces2e,UGT1A2,CES1C,ITPA,UGT1A7,UGT1A9,UPP2,TK1 |
| Metabolic pathways | RDH10,MGAT3A,PKMB,PISD,DPM3,TKTL2,UGT2A3,PAFAH1B3,HK2,IVD |
Protein Function
HPRT1 has several biochemical functions, for example, guanine phosphoribosyltransferase activity,hypoxanthine phosphoribosyltransferase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPRT1 itself. We selected most functions HPRT1 had, and list some proteins which have the same functions with HPRT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | GRHPR,RPS19,GRPEL1,RQCD1,PML,CADM4,PDCD6,P2RX7,ERBB3,ID1 |
| protein binding | COMTD1,TRIAP1,CTNNAL1,ASPH,COX5A,PACS1,SNRNP25,NAPG,GNG5,CTLA2B |
| magnesium ion binding | OPA1,LHPP,NUDT18,SRPK1,STK11,PPA1A,ARF1,PIF1,ENDOV,PPM1AA |
| nucleotide binding | MAPK14B,ACTB2,MAPK12A,MATR3L,MYO7A,MSI1,YTHDC2,DYNC2H1,RAB3DA,SIK2A |
| hypoxanthine phosphoribosyltransferase activity | HPRT1L |
Interacting Protein
HPRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HPRT1.
WDYHV1;PRTFDC1;SDCBP;ISCU;EIF1B;HUS1;EPB41;MCC
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