HNF4A
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Official Full Name
HNF4A hepatocyte nuclear factor 4, alpha -
Synonyms
HNF4A;hepatocyte nuclear factor 4, alpha;MODY, MODY1, TCF14;hepatocyte nuclear factor 4-alpha;HNF4;NR2A1;TCF-14;HNF-4-alpha;HNF4alpha10/11/12;transcription factor 14;transcription factor-14;transcription factor HNF-4;hepatic nuclear factor 4 alpha;nuclear receptor subfamily 2 group A member 1;TCF;MODY;MODY1;TCF14;HNF4a7;HNF4a8;HNF4a9;NR2A21;HNF4alpha;FLJ39654
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- His&Myc
- Flag
Involved Pathway
HNF4A involved in several pathways and played different roles in them. We selected most pathways HNF4A participated on our site, such as AMPK signaling pathway,Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | ONECUT1,PAX6,PAX4,INS2,RFX6,HNF4G,MNX1,NEUROD1,HES1,MAFA |
| AMPK signaling pathway | CCND1,PIK3CD,ULK1,MLYCD,SLC2A4,G6PC,PIK3R5,PCK1,PIK3CA,CRTC2 |
Protein Function
HNF4A has several biochemical functions, for example, DNA binding,RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF4A itself. We selected most functions HNF4A had, and list some proteins which have the same functions with HNF4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | FOXM1,SFPQ,CTCF,CCNT1,FOXC2,FOXA2,TNF,HIVEP2,TCF7L2,WNT5A |
| protein homodimerization activity | SETMAR,PLCB1,GPD1,RAB11FIP3,SUPV3L1,MYO7A,BHLHB9,ADSSL1,GALE,HOMER2 |
| protein binding | ZFPM2A,SART1,COX4I1,NUDT22,PMEPA1,UNC13B,UBXN4,COLGALT2,HSPA4L,CEP152 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR5A1B,NR6A1,NR5A1,NR1H4,NR1D2,NR1I3,RORB,PTGER3,HNF4G,RORA |
| DNA binding | SREBF1,HOXC9,ZNF285A,ZNF572,MSXC,HIST1H3H,SATB1A,SIX6,HOXC3A,TBX24 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | MYOD1,FOXC2,TLE4,NKX2-5,MEIS1,GTF2IRD1,PAX3,GLI1,HIF1A,ATF1 |
| transcription factor activity, sequence-specific DNA binding | TRIM29,GABPA,TARDBP,SCAND2P,PA2G4,GTF2H3,ZNF354A,ZNF75D,IRF6,NFIL3-2 |
| zinc ion binding | RNF214,TRIM58,MYLIPB,KPNB1,PHC3,ZDHHC14,TRIM35-22,DIDO1,DBF4,ADAMTSL1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CREB1,HIF1A,MYOCD,FOXJ1,TXK,ATF4,HOXA5,BCL11B,SIX2,PITX2 |
Interacting Protein
HNF4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF4A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF4A.
PPARGC1A;st2a1_human_hnf4a-6160-site_dna-probe
Resources
Research Area
Early Endodermal Lineage MarkersEpithelial Stem Cell Transcription Factors
Negative Regulators of EMT
Endodermal Lineage Markers
Related Services
Related Products
References
- Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).
- Pihoker, C; Gilliam, LK; et al. Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 98:4055-4062(2013).
