HLA-A
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Official Full Name
major histocompatibility complex, class I, A -
Overview
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. -
Synonyms
HLA-A;major histocompatibility complex, class I, A;HLA class I histocompatibility antigen, A-1 alpha chain;antigen presenting molecule;leukocyte antigen class I-A;MHC class I antigen HLA-A heavy chain;HLAA;FLJ26655
Recombinant Proteins
- Human
- E.coli
- Wheat Germ
- HEK293
- HEK
- Insect Cell
- HEK293T
- Mamanlian cells
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Avi
- His&Myc
- Flag
- Avi
- His&B2M
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-A-3396H | Recombinant Human HLA-A protein, His-tagged | E.coli | Human | His | 28-303 aa | |
| HLA-A-4832H | Recombinant Human HLA-A Protein, GST-tagged | Wheat Germ | Human | GST | 24-365 a.a. |
|
| HLA-A-938H | Recombinant Human HLA-A protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| HLA-A-5503HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
|
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| HLA-A-01H | Recombinant Human HLA-A Protein, C-His tagged | HEK | Human | His |
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| HLA-A-068H | Recombinant HLA-A*0201 WT-1 (RMFPNAPYL) complex protein, His-Avi-tagged | HEK293 | Human | His&Avi | It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and RMFPNAPYL peptide design |
|
| HLA-A-069H | Recombinant Human HLA-A protein, His-Avi-tagged | HEK293 | Human | His&Avi | Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and RMFPNAPYL peptide |
|
| HLA-A-1448H | Recombinant Human HLA-A protein, His-tagged | Insect Cell | Human | His | 25-308aa |
|
| HLA-A-1500H | Recombinant Human HLA-A protein, His&Myc-tagged | E.coli | Human | His&Myc | 25-308aa |
|
| HLA-A-2242H | Recombinant Human HLA-A Protein, His-tagged | E.coli | Human | His | Tyr83-Ser352 |
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| HLA-A-2390H | Recombinant Human HLA-A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| HLA-A-2623HFL | Recombinant Full Length Human HLA-A protein, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
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| HLA-A-2935H | Recombinant Human HLA-A Protein (Gly25-Trp298), N-His tagged | E.coli | Human | His | Gly25-Trp298 |
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| HLA-A-2936H | Recombinant Human HLA-A Protein (Gly25-Leu300), N-His tagged | E.coli | Human | His | Gly25-Leu300 |
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| HLA-A-2937H | Recombinant Human HLA-A Protein (Full Length), Avi tagged | E.coli | Human | Avi | Full L. Full Length |
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| HLA-A-2938H | Recombinant Human HLA-A Protein (Met1-Pro304), C-His and Avi tagged | Mammalian cells | Human | His&Avi | Met1-Pro304 |
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| HLA-A-3557HF | Recombinant Full Length Human HLA-A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 24-365 amino acids |
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| HLA-A-3958H | Recombinant Human HLA-A protein, His-tagged | E.coli | Human | His | 25-308aa |
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| HLA-A-4302H | Recombinant Human HLA-A protein, His-B2M-tagged | E.coli | Human | His&B2M | 25-299aa |
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| HLA-A-573HB | Recombinant Human HLA-A*0201 NY-ESO-1 (SLLMWITQC) complex protein, His-Avi-tagged, Biotinylated | HEK293 | Human | His&Avi | It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and SLLMWITQC peptide. |
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| HLA-A-730HP | Recombinant Human HLA-A complex Protein (tetramer), His-Avi-tagged, PE-Labeled | HEK293 | Human | His&Avi | Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M) and SLLMWITQC peptide |
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| HLA-A-732H | Recombinant Human HLA-A0201 gp100 (YLEPGPVTA) complex protein, His-Avi-tagged | HEK293 | Human | His&Avi | It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and YLEPGPVTA peptide design. |
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| HLA-A-733H | Recombinant Human HLA-A0201 MAGE-A4 (GVYDGREHTV) complex protein, His-Avi-tagged | HEK293 | Human | His&Avi | It contains Gly 25 - Thr 305 (HLA-A*0201),Ile21-Met119 (B2M) and GVYDGREHTV peptide design |
|
Involved Pathway
HLA-A involved in several pathways and played different roles in them. We selected most pathways HLA-A participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Autoi | FASLG,CD40,HLA-DRB3,Ifna15,TSHR,Ifna11,PRF1,TPO,IFNA21,IFNA7 |
| HTLV-I infection | HLA-DOA,CANX,HLA-DOB,NFKB1,RRAS,VCAM1,FZD1,HLA-DRA,WNT3,SLC25A5 |
| Viral carcinogenesis | IRF7,POLB,STAT5A,RBL2,ACTN1,KRAS,LYN,MAD1L1,PIK3R1,KAT2A |
| Cell adhesion molecules (CAMs) | PVR,CD28,CLDN15LA,TIGIT,ICOSLG,ITGA6B,HLA-DRB1,CLDNH,CLDN11,CADM1A |
| Herpes simplex infection | CCL2,MYD88,CUL1,BMA2,CLOCKB,PER3,PPP1CBL,TAF6,TRAF2,IKBKB |
| Natural killer cell mediated cytotoxicity | ARAF,KIR2DL1,RAC2,PPP3R1,IFNAR1,SH2D1A,IFNA7,ULBP2,PTPN6,IFNA17 |
| Epstein-Barr virus infection | RELA,TP53,HDAC2,HSPA1B,PIK3R3,POLR2I,CD40,YWHAE,AKT2,POLR2L |
| Antigen processing and presentation | KIR2DS4,RFX5,PSME1,HLA-C,HSP90AB1,HLA-B,KIR2DS2,HLA-DRB1,HLA-F,HLA-DPA1 |
| Endocytosis | DAB2,SPG20,GRK7A,TGFBR1A,CHMP3,HSPA1A,CHMP6,EEA1,CYTH4,CLINT1A |
Protein Function
HLA-A has several biochemical functions, for example, T cell receptor binding,TAP binding,beta-2-microglobulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-A itself. We selected most functions HLA-A had, and list some proteins which have the same functions with HLA-A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | FASTKD5,STRAP,SAMD4,CRKL,CLTC,WIBG,TMSB4X,G3BP1,PDCD11,LGALS1 |
| peptide antigen binding | CLEC4M,HLA-DRB5,MHC1ZHA,HLA-DQA1,CD209,TAP1,HLA-F,HLA-G,MHC1UKA,MAML1 |
| beta-2-microglobulin binding | FCGRT,H2-Q10,CD1d1,HLA-E,CD1A,CD1C,CD1E,CD1D,HFE,CD1D2 |
| TAP binding | HLA-C,H2-Q10,HLA-B |
| T cell receptor binding | CD3G,EPS8L1,DOCK2,H2-Q10,FYN,CD1d1,CD3E |
| receptor binding | PVRL3,CCL13,UFD1L,MBL2,TENM2,NRG2B,NXPH3,CD160,FGF11,FGF6B |
| protein binding | ANKRD54,APOA4,HAUS1,RAB5B,SLC22A7,MAPKBP1,ELK3,MTPAP,ZBTB48,TMEM120B |
Interacting Protein
HLA-A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-A here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-A.
B2M;ganglioside_gm1;Cep85l;Bmpr1a;ATXN3;Arhgef17;PCDHB15
Resources
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References
- Olvera, A; Perez-Alvarez, S; et al. The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression. AIDS 29:507-517(2015).
- Kusnierczyk, P; Mozer-Lisewska, I; et al. Contribution of genes for killer cell immunoglobulin-like receptors (KIR) to the susceptibility to chronic hepatitis C virus infection and to viremia. HUMAN IMMUNOLOGY 76:102-108(2015).
