GZMH

  • Official Full Name

    granzyme H (cathepsin G-like 2, protein h-CCPX)

  • Overview

    The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine;proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like;activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3 and;P4 positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the;cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in;pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein;isoforms.

  • Synonyms

    GZMH;granzyme H (cathepsin G-like 2, protein h-CCPX);CTSGL2;granzyme H;CCP X;CGL 2;CSP C;CTLA1;Cathepsin G like 2;CGL2;Cytotoxic serine protease C;Cytotoxic T lymphocyte associated serine esterase 1;Cytotoxic T lymphocyte proteinase;EC 3.4.21.-;Protein h CCPX;OTTHUMP00000178753;OTTHUMP00000245745;cathepsin G-like 2;cytotoxin serine protease-C;cytotoxic T-lymphocyte proteinase;cytotoxic T-lymphocyte-associated serine esterase 1;CCP-X;CGL-2;CSP-C

Recombinant Proteins

  • Human
  • HEK293
  • NS0
  • Wheat Germ
  • Human Cell
  • E.coli
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&T7
Cat.# Product name Source (Host) Species Tag Protein Length Price
GZMH-297H Recombinant Human GZMH protein, His-tagged HEK293 Human His Met1-Leu246
GZMH-01HFL Recombinant Full Length Human GZMH Protein, C-His-tagged NS0 Human His Full L. Glu19-Leu246
GZMH-4521H Recombinant Human GZMH Protein, GST-tagged Wheat Germ Human GST
GZMH-2943HCL Recombinant Human GZMH cell lysate Human Cell Human Non
GZMH-1856H Recombinant Human GZMH protein, His & T7-tagged E.coli Human His&T7 Glu19~Leu246
GZMH-3390HF Recombinant Full Length Human GZMH Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 246 amino acids
GZMH-3646H Recombinant Human GZMH Protein (Glu19-Leu246), N-His tagged E.coli Human His Glu19-Leu246

    Involved Pathway

    GZMH involved in several pathways and played different roles in them. We selected most pathways GZMH participated on our site, such as Metabolism of Angiotensinogen to Angiotensins,Metabolism of proteins,Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GZMH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Peptide hormone metabolism RAB27A,MBOAT4,SLC30A5,CPB1,GPR120,PCSK2,CPN1,ACE,INHBAA,INHA
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) IGF2B,IGFBP1B,IGFBP2A,IGFBP2,IGFBP6,PAPPA,PAPPA2,KLK13,IGFBP6A,IGFBP4
    Metabolism of Angiotensinogen to Angiotensins ACE,CTSG,CPA3,CPB2,CMA1,CPB1,ATP6AP2
    Metabolism of proteins IGF2B,ADD1,TUBA1B,HYOU1,IGFBP2B,FBXW2,SCFD1,TIMM10,CTDSP2,TIMM50

    Protein Function

    GZMH has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GZMH itself. We selected most functions GZMH had, and list some proteins which have the same functions with GZMH. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase activity PRSS28,CTRB1,Acr,CTRC,PCSK2,PRTN3,CORIN,PRSS30,TPP2,KLK9

    Interacting Protein

    GZMH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GZMH here. Most of them are supplied by our site. Hope this information will be useful for your research of GZMH.

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    Resources

    Research Area

    Granzyme
    Cytotoxic T Cells (CTLs)

    References

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