GUCA1A
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Official Full Name
guanylate cyclase activator 1A (retina) -
Overview
This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. -
Synonyms
GUCA1A;guanylate cyclase activator 1A (retina);C6orf131, chromosome 6 open reading frame 131 , GUCA, GUCA1;guanylyl cyclase-activating protein 1;COD3;cone dystrophy 3;dJ139D8.6;GCAP;GCAP1;GCAP 1;guanylin 1, retina;guanylate cyclase-activating
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- Wheat Germ
- Insect Cell
- Mammalian Cell
- HEK293T
- Insect Cells
- In Vitro Cell Free System
- HEK293
- Non
- His
- GST
- Myc&DDK
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GUCA1A-28157TH | Recombinant Human GUCA1A | Wheat Germ | Human | Non | 201 amino acids |
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| GUCA1A-407H | Recombinant Human GUCA1A, Gly & Pro tagged | Insect Cell | Human | His | 1-201 a.a. |
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| GUCA1A-4482H | Recombinant Human GUCA1A Protein, GST-tagged | Wheat Germ | Human | GST |
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| GUCA1A-487H | Recombinant Human GUCA1A, His-GST tagged | Insect Cell | Human | His | 1-201 a.a. |
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| GUCA1A-5893C | Recombinant Chicken GUCA1A | Mammalian Cell | Chicken | His |
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| GUCA1A-7383M | Recombinant Mouse GUCA1A Protein | Mammalian Cell | Mouse | His |
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| GUCA1A-9374Z | Recombinant Zebrafish GUCA1A | Mammalian Cell | Zebrafish | His |
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| GUCA1A-001HCL | Recombinant Human GUCA1A cell lysate | Insect Cell | Human | Non |
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| GUCA1A-002HCL | Recombinant Human GUCA1A cell lysate | Insect Cell | Human | Non |
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| GUCA1A-1746H | Recombinant Human GUCA1A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| GUCA1A-1989H | Recombinant Human GUCA1A protein | Insect Cells | Human | Non | Met1-Gly201 |
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| GUCA1A-226HF | Recombinant Full Length Human GUCA1A Protein | In Vitro Cell Free System | Human | Full L. 201 amino acids |
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| GUCA1A-2379H | Recombinant Human GUCA1A protein(Met1-Gly201), His&GST-tagged | Insect Cells | Human | His&GST | Met1-Gly201 |
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| GUCA1A-2549H | Recombinant Human GUCA1A Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| GUCA1A-3340HF | Recombinant Full Length Human GUCA1A Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 201 amino acids |
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| GUCA1A-4006M | Recombinant Mouse GUCA1A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GUCA1A-4006M-B | Recombinant Mouse GUCA1A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GUCA1A involved in several pathways and played different roles in them. We selected most pathways GUCA1A participated on our site, such as Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phototransduction | GC3,GRK7A,CALM1,GUCA1B,CALM3,EXORH,RGS9A,GNGT1,CALM2,GNAT2 |
Protein Function
GUCA1A has several biochemical functions, for example, calcium ion binding,calcium sensitive guanylate cyclase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCA1A itself. We selected most functions GUCA1A had, and list some proteins which have the same functions with GUCA1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH10,JAG2,GUCA1E,S100A13,SYT10,PLA2G12B,GCA,PROC,C2CD4B,NINL |
| calcium sensitive guanylate cyclase activator activity | GUCA1G,GUCA1C,GUCA1E,GUCA1B,GUCA1D,GUCA2B,RCVRN |
Interacting Protein
GUCA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCA1A.
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References
- Zobor, D; Zrenner, E; et al. GUCY2D- OR GUCA1A-RELATED AUTOSOMAL DOMINANT CONE-ROD DYSTROPHY Is There a Phenotypic Difference?. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 34:1576-1587(2014).
- Lopez-del Hoyo, N; Lopez-Begines, S; et al. Functional EF-Hands in Neuronal Calcium Sensor GCAP2 Determine Its Phosphorylation State and Subcellular Distribution In Vivo, and Are Essential for Photoreceptor Cell Integrity. PLOS GENETICS 10:-(2014).
