GRIN2B

  • Official Full Name

    glutamate receptor, ionotropic, N-methyl D-aspartate 2B

  • Overview

    N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

  • Synonyms

    GRIN2B;glutamate receptor, ionotropic, N-methyl D-aspartate 2B;MRD6;NR2B;hNR3;GluN2B;NMDAR2B;glutamate receptor ionotropic, NMDA 2B;NR3;glutamate receptor subunit epsilon-2;N-methyl-D-aspartate receptor subunit 3;N-methyl D-aspartate receptor subtype 2B;glutamate [NMDA] receptor subunit epsilon-2

Recombinant Proteins

  • Human
  • Rat
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • Protein Conjugation
  • His
  • His&GST
  • Non
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GRIN2B-13535H Recombinant Human GRIN2B, His-tagged E.coli Human His C-term-352a.a.
GRIN2B-1354H Recombinant Human GRIN2B protein, His & GST-tagged E.coli Human His&GST Ile35~Asp557
GRIN2B-2701R Recombinant Rat GRIN2B Protein Mammalian Cell Rat His
GRIN2B-29049TH Recombinant Human GRIN2B Wheat Germ Human Non 110 amino acids
GRIN2B-1915H Recombinant Human GRIN2B protein, His-tagged HEK293 Human His Arg 27 - Met 394
GRIN2B-2355R Recombinant Rat GRIN2B Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
GRIN2B-2355R-B Recombinant Rat GRIN2B Protein Pre-coupled Magnetic Beads HEK293 Rat
GRIN2B-2546H Recombinant Human GRIN2B Protein (Tyr1133-Val1484), N-His tagged E.coli Human His Tyr1133-Val1484
Grin2b-2814R Recombinant Rat Grin2b Protein, His-tagged, OVA Conjugated Protein Conjugation Rat His Pro1113-Cys1122
GRIN2B-2848H Recombinant Human GRIN2B protein(1251-1380 aa), C-His-tagged E.coli Human His 1251-1380 aa
GRIN2B-5345H Recombinant Human GRIN2B Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    GRIN2B involved in several pathways and played different roles in them. We selected most pathways GRIN2B participated on our site, such as Ras signaling pathway,Rap signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction DRD1A,GNRHR1,GRPR,LPAR3,GRID1,TACR1A,NPY7R,P2RX6,VIPR1,NMUR1
    Cocaine addiction DRD1,GRM3,GRIN3A,GRIN2C,NFKB1,TH,CREB3,GRIN2A,GRIN2D,CDK5R1
    cAMP signaling pathway GRIN2D,ROCK2,PLD1,LOC100328615,NPY1R,RAC1,CALML5,RAP1B,RAP1A,CNGA4
    Long-term potentiation PRKACB,MAPK3,CALM4,PPP3R2,GRM5,MAPK1,HRAS,ATF4,PRKCB,PPP1R1A
    Alcoholism HIST1H4A,NRAS,H2BFWT,HIST1H2BK,SLC18A1,SOS1,HIST1H4G,GNG8,HIST2H3A,GM14477
    Circadian entrainment ITPR3,PLCB3,GNGT2,PLCB1,GNB2,AKR1C1,MTNR1A,GRIA4,MTNR1B,PRKCA
    Alzheimers disease GNAQ,NDUFC2-KCTD14,CALM4,NDUFB11,PPP3CA,COX4I1,IDE,CDK5R1,APOE,COX6A2
    Nicotine addiction GRIN3A,GABRA2,GABRG3,GABRE,GRIN2C,GABRQ,GRIA4,GABRB3,GRIN2A,GABRR3
    Rap signaling pathway SIPA1L2,RALGDS,MAGI2,ACTB,PLCB3,CDC42,FGF21,IGF1R,PIK3CG,PRKD1

    Protein Function

    GRIN2B has several biochemical functions, for example, NMDA glutamate receptor activity,calcium channel activity,extracellular-glutamate-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN2B itself. We selected most functions GRIN2B had, and list some proteins which have the same functions with GRIN2B. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding RORAA,RNF180,TAF15,ADH1C,PGLYRP5,CDADC1,OAS1A,LIN28A,CSRP1A,MMP13A
    NMDA glutamate receptor activity GRIN2C,GRIN3A,GRIN1A,GRIN3B,GRIN2A,GRIN1B,GRIN2D,GRIN2BB
    extracellular-glutamate-gated ion channel activity KBP,GRIN1,GRIA2,GRIK4,GRID2,GRIK1,GRIA3A,GRIN2BB,GRIN1A,GRID1
    protein binding IFIH1,SEC23IP,PCNA,ZNF649,BAZ2B,CYCS,ITM2C,RTN3,VPS16,TIMM21
    glycine binding GSS,GLRA2,SRR,GRIN1,GNMT,GRIN3A,ALAS2,GLDC,GLRA1,SIX2A
    calcium channel activity CACNA1BA,TRPV1,CUL5,GPM6A,CATSPER2,RYR1B,TRPM8,MCU,CACNA2D3,CACNG1A

    Interacting Protein

    GRIN2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN2B here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN2B.

    CAMK2A;Dlg4;DLG4;Dlg3;PPP1CA;MAGI3;PTPRC;PTPRB;PTPRG;PPP3CA;PTPN12

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