GPX1
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Official Full Name
glutathione peroxidase 1 -
Overview
Glutathione peroxidase 1 (GPX1) is a cytosolic selenoprotein which reduces hydrogen peroxide to water. GPX1 is the most abundant and ubiquitous among the five GPX isoforms identified so far. It is an important component in the anti-oxidative defense in ce -
Synonyms
GPX1;glutathione peroxidase 1;GPx-1;GSHPx-1;cellular glutathione peroxidase;GPXD;GSHPX1;MGC14399;MGC88245
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Human
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Erythrocytes
- His
- Non
- GST&His
- Avi&Fc&His
- His&SUMO
- GST
Involved Pathway
GPX1 involved in several pathways and played different roles in them. We selected most pathways GPX1 participated on our site, such as Glutathione metabolism,Arachidonic acid metabolism,Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | DCTN2,mt-Atp8,NDUFB1,NDUFB9,SDHC,NDUFB2,NDUFA4,NDUFA8,COX6B1,COX5A |
| Glutathione metabolism | GSTT1B,IDH2,GPX1A,SRM,GSTM6,GPX4B,GSS,ANPEP,GPX5,GGT1 |
| Amyotrophic lateral sclerosis (ALS) | PRPH,TNFRSF1B,MAPK14,PPP3R1,APAF1,BCL2L1,BAX,BAD,GRIA1,BID |
| Thyroid hormone synthesis | CREB3L2,GNAS,TPO,PLCB1,GSR,FXYD2,DUOX2,CANX,DUOXA2,PLCB3 |
| Arachidonic acid metabolism | ALOX5AP,LTC4S,PLA2G12A,CYP2P6,FAAH2A,PTGESL,CYP2C8,CYP2C9,CYP4F11,AKR1C21 |
Protein Function
GPX1 has several biochemical functions, for example, SH3 domain binding,glutathione binding,glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX1 itself. We selected most functions GPX1 had, and list some proteins which have the same functions with GPX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione peroxidase activity | PRDX6,MGST2,GSTK1,GPX2,GPX6,GSTZ1,GPX7,GRX2,GPX5,LTC4S |
| phospholipid-hydroperoxide glutathione peroxidase activity | GPX4 |
| selenium binding | DIO2,SELENBP1,SEPP1,GPX3,SEP15,RPH3A,SELENBP2,SELT,DIO1 |
| SH3 domain binding | CYBA,PLSCR1,ARHGAP1,SHANK1,NOXA1,SH3BP5LA,SH3BGR,DNAJC6,MVB12A,PTPN12 |
| glutathione binding | LTC4S,PTGES2,GSTM1,PTGESL,LANCL1,GSTP2,GSS,GSTM4,PTGES,GSTM2 |
Interacting Protein
GPX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX1.
glutathione;fumaric acid;MAPK6;SIRT4
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References
- Guo, X; Yu, Y; et al. Heterologous expression and characterization of human cellular glutathione peroxidase mutants. IUBMB LIFE 66:212-219(2014).
- Zemolin, APP; Meinerz, DF; et al. Evidences for a role of glutathione peroxidase 4 (GPx4) in methylmercury induced neurotoxicity in vivo. TOXICOLOGY 302:60-67(2012).
