GPA33
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Official Full Name
glycoprotein A33 (transmembrane) -
Overview
The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. -
Synonyms
GPA33;glycoprotein A33 (transmembrane);cell surface A33 antigen;A33;transmembrane glycoprotein A33;MGC129986;MGC129987
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rat
- HEK293
- Human Cells
- E.coli
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Fc
- Non
- His&T7
- Myc&DDK
- GST
- His&Avi
Involved Pathway
GPA33 involved in several pathways and played different roles in them. We selected most pathways GPA33 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GPA33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GPA33 has several biochemical functions, for example, protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPA33 itself. We selected most functions GPA33 had, and list some proteins which have the same functions with GPA33. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MED26,SETD8,STX10,COPS4,SCAF8,KDM5B,CMKLR1,VEGFC,PYY,TRIP13 |
| receptor activity | NOTCH4,TNFRSF11B,VMN1R54,RRBP1B,GFRA1B,PVRL3,TRAM1,LRRN2,VMN1R49,NLGN1 |
Interacting Protein
GPA33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPA33 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPA33.
POT1;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
Resources
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References
- Tome-Amat, J; Menendez-Mendez, A; et al. Production and characterization of scFvA33T1, an immunoRNase targeting colon cancer cells. FEBS JOURNAL 279:3022-3032(2012).
- Carreras-Sangra, N; Tome-Amat, J; et al. Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin -sarcin. PROTEIN ENGINEERING DESIGN & SELECTION 25:425-435(2012).
