GP6
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Official Full Name
glycoprotein VI (platelet) -
Overview
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor;for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded;protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon;collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively;spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
GP6;glycoprotein VI (platelet);platelet glycoprotein VI;GPVI;Glycoprotein VI;GPIV;MGC138168;Platelet collagen receptor;Platelet glycoprotein VI precursor;glycoprotein 6;BDPLT11
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- E.coli
- Mus musculus
- Mammalian cells
- HEK293
- C-His
- E.coli
- E.coli expression system
- His
- Non
- His&SUMO
- Fc
- His&Fc&Avi
Involved Pathway
GP6 involved in several pathways and played different roles in them. We selected most pathways GP6 participated on our site, such as ECM-receptor interaction,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | ITGA9,ITGB6,SDC1,ITGB7,LAMB2,Itga10&Itgb1,ITGA4,ITGA1,SPP1,COL27A1A |
| Platelet activation | PIK3CB,PIK3R1,AKT2,MAPK12,ITGB1,GUCY1A3,GP5,PIK3CG,FERMT3,PLA2G4A |
Protein Function
GP6 has several biochemical functions, for example, collagen binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GP6 itself. We selected most functions GP6 had, and list some proteins which have the same functions with GP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | Pdgfa&Pdgfb,TLL1,Itga10&Itgb1,LUM,PCOLCE2,SERPINH1,PAK1,DCN,MMP9,DDR1 |
| receptor activity | ITGB1A,LILRB2,CRLF1,JMJD6,CRTAM,LYVE1,KLRC4-KLRK1,CADM1B,TEK,CD46 |
| protein binding | VPS11,LCP2,MAPKBP1,PIKFYVE,ADAP1,RPS19BP1,PTPN11A,FABP5,PDK3,STAT3 |
| transmembrane signaling receptor activity | GABRQ,CD3E,P2RX5,IL4R.1,GPR182,FZD8A,LGR4,FZD7A,CD300C,VIPR1B |
Interacting Protein
GP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GP6.
CALM1;FYN;YES1;LYN;FCER1G
Resources
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References
- Hassapis, KA; Stylianou, DC; et al. Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines. VIRUSES-BASEL 6:5047-5076(2014).
- Guo, FC; Liu, Y; et al. Human Papillomavirus Infection and Esophageal Squamous Cell Carcinoma: A Case-Control Study. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 21:780-785(2012).
