GNMT
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Official Full Name
glycine N-methyltransferase -
Overview
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). -
Synonyms
GNMT;glycine N-methyltransferase;EC 2.1.1.20;Glycine N methyltransferase;GNMT_HUMAN;OTTHUMP00000016412
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GNMT involved in several pathways and played different roles in them. We selected most pathways GNMT participated on our site, such as Glycine, serine and threonine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycine, serine and threonine metabolism | AGXTA,AOC2,MAOA,GAMT,BHMT,CHDH,AMT,CTH,GATM,GCSH |
Protein Function
GNMT has several biochemical functions, for example, folic acid binding,glycine N-methyltransferase activity,glycine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNMT itself. We selected most functions GNMT had, and list some proteins which have the same functions with GNMT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycine binding | SIX2A,GRIN3A,GRIN2B,ALAS2,GLRA4A,GRIN3B,GLDC,GRIN1,GSS,GLRA2 |
| folic acid binding | MTHFS,DAAM2,FOLR2,FOLR3,FTCD,TYMS,DHFR,SLC19A1,DMGDH,SLC46A1 |
| protein binding | SNRNP40,NEBL,TRAF1,PIP5K1B,SCRN2,TOMM34,RAB3C,FOXO3,SNRPD2,MYLK |
Interacting Protein
GNMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNMT here. Most of them are supplied by our site. Hope this information will be useful for your research of GNMT.
ARRB1;RPSA;ARR3;TERF1;TERF2;NUDT18;HDAC7;TINF2;NIF3L1;PLEKHF2;POT1;TERF2IP
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References
- Martinez-Una, M; Varela-Rey, M; et al. S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease. JOURNAL OF HEPATOLOGY 62:673-681(2015).
- Fernandez-Alyarezl, S; Gutierrez-de Juan, V; et al. TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. LABORATORY INVESTIGATION 95:223-236(2015).
