GMNN
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Official Full Name
geminin, DNA replication inhibitor -
Overview
GMNN inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. -
Synonyms
GMNN;geminin, DNA replication inhibitor;geminin;Gem
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- His&GST
- His&T7
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GMNN involved in several pathways and played different roles in them. We selected most pathways GMNN participated on our site, such as Assembly of the pre-replicative complex,Association of licensing factors with the pre-replicative complex,CDT1 association with the CDC6:ORC:origin complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with GMNN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CDT1 association with the CDC6:ORC:origin complex | CDT1,MCM8 |
| DNA Replication | MCM6L,POLD4,RPA4,RFC4,RFC3,POLE,MCM6,GINS3,POLE4,DBF4 |
| Cell cycle | DMC1,CHEK2,TP53,DCTN1A,ODF2B,BUB3,GADD45AB,CKAP5,LMNB1,ENSAA |
| DNA Replication Pre-Initiation | DBF4,MCM10,CDT1 |
| Assembly of the pre-replicative complex | E2F2,MCM8,E2F3,CDT1,E2F1 |
| Association of licensing factors with the pre-replicative complex | E2F2,E2F1,CDT1,E2F3 |
| Cell Cycle, Mitotic | SGOL1,DCTN3,PCM1,TUBG2,USO1,GORASP1,CEP78,GORASP2,CNEP1R1,NDEL1 |
Protein Function
GMNN has several biochemical functions, for example, histone deacetylase binding,protein binding,repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GMNN itself. We selected most functions GMNN had, and list some proteins which have the same functions with GMNN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | SOD3,BRD7,SAP18,PFDN5,CDX2,ZFPM1,DAXX,BHLHE40,YY1,KCNA3 |
| histone deacetylase binding | HDAC4,CBX5,PKN2,KLF4,PARK2,SP2,RUNX2,CRY1,ZNF703,NKX3-1 |
| repressing transcription factor binding | EIF4E,MYC,HDAC4,MAGEA2,CBX5,HDAC9,NFYB,PRDM5,HMGB1,TCF3 |
| protein binding | PKP1,PYCARD,LRRC26,MAT2B,CXCR7,TJP1,SFRS9,ECE2,ETV5,AGAP2 |
Interacting Protein
GMNN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GMNN here. Most of them are supplied by our site. Hope this information will be useful for your research of GMNN.
CDT1;MCIDAS;CCDC146
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