GJA4
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Official Full Name
gap junction protein, alpha 4, 37kDa -
Overview
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. -
Synonyms
GJA4;gap junction protein, alpha 4, 37kDa;gap junction protein, alpha 4, 37kD (connexin 37) , gap junction protein, alpha 4, 37kDa (connexin 37);gap junction alpha-4 protein;connexin 37;CX37;Connexin-37;CXA4_HUMAN;Gap junction alpha 4 protein;gap junction protein, alpha 4 37kDa (connexin 37);gap junction protein, alpha 4, 37kD (connexin 37);OTTHUMP00000004181;OTTHUMP00000004182
Recombinant Proteins
- Rat
- Human
- Mouse
- Chicken
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Xenopus laevis
- Mus musculus
- Bovine
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&GST
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GJA4-2547R | Recombinant Rat GJA4 Protein | Mammalian Cell | Rat | His |
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| GJA4-26253TH | Recombinant Human GJA4 | Wheat Germ | Human | Non | 333 amino acids |
|
| GJA4-6370M | Recombinant Mouse GJA4 Protein | Mammalian Cell | Mouse | His |
|
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| GJA4-6996H | Recombinant Human GJA4 protein, His-tagged | E.coli | Human | His | Val79~Ser328 |
|
| Gja4-6997M | Recombinant Mouse Gja4 protein, His & GST-tagged | E.coli | Mouse | His&GST | Thr19~Asp245 |
|
| GJA4-7107C | Recombinant Chicken GJA4 | Mammalian Cell | Chicken | His |
|
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| GJA4-5922HCL | Recombinant Human GJA4 293 Cell Lysate | HEK293 | Human | Non |
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| GJA4-191HF | Recombinant Full Length Human GJA4 Protein | In Vitro Cell Free System | Human | Full L. 333 amino acids |
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| GJA4-2203R | Recombinant Rat GJA4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GJA4-2203R-B | Recombinant Rat GJA4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GJA4-3571M | Recombinant Mouse GJA4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GJA4-3571M-B | Recombinant Mouse GJA4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GJA4-4922H | Recombinant Human GJA4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GJA4-5291HF | Recombinant Full Length Human GJA4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 333 amino acids |
|
| RFL12524RF | Recombinant Full Length Rat Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (2-333) |
|
| RFL19593HF | Recombinant Full Length Human Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (2-333) |
|
| RFL29813XF | Recombinant Full Length Xenopus Tropicalis Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged | E.coli expression system | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | His | Full L. Full Length of Mature Protein (2-352) |
|
| RFL2986XF | Recombinant Full Length Xenopus Laevis Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged | E.coli expression system | Xenopus laevis | His | Full L. Full Length of Mature Protein (2-352) |
|
| RFL35221MF | Recombinant Full Length Mouse Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (2-333) |
|
| RFL7509BF | Recombinant Full Length Bovine Gap Junction Alpha-4 Protein(Gja4) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length of Mature Protein (2-333) |
|
Involved Pathway
GJA4 involved in several pathways and played different roles in them. We selected most pathways GJA4 participated on our site, such as Calcium Regulation in the Cardiac Cell,Gap junction assembly,Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vesicle-mediated transport | HSPH1,MYO1C,CX30.3,MYO6B,DTNBP1B,MYO6A,CNO,SNX9,BLOC1S4,SEC22C |
| Calcium Regulation in the Cardiac Cell | GJA8,CASQ2,CASQ1B,GJC2,CX34.4,GJB1,RGS11,CX27.5,GNB3B,CHRM1 |
| Gap junction trafficking and regulation | GJA8,GJB5,CX30.3,GJA5,GJC1,GJD3,DAB2,MYO6B,MYO6,GJB4 |
| Gap junction trafficking | GJD3,DAB2,GJB5,GJB2,MYO6A,CX30.3,CX27.5,GJC1,GJB7,GJA5 |
| Gap junction assembly | GJA5,GJA8,GJB4,CX30.3,GJB5,GJB3,GJB2,GJB7,CX27.5,GJD3 |
| Membrane Trafficking | PICALMA,SNX9,CLVS2,MYO6,EXOC6,BLOC1S1,ARCN1B,TRAPPC6B,TMED2,SEC16B |
| Ovarian Infertility Genes | SYNE2,ZP2,INHA,MSH5,DMC1,NRIP1,NR5A1,ZP3,DAZL |
Protein Function
GJA4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA4 itself. We selected most functions GJA4 had, and list some proteins which have the same functions with GJA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAPRE3,SHC3,SLC25A6,DNPEP,DENR,PAFAH1B3,SRI,MED28,ITGA6,WASF2 |
Interacting Protein
GJA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA4.
OPRM1;Oprd1;OPRK1
Resources
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References
- Luana, NT; Sharma, N; et al. Characterization and cardiac differentiation of chicken spermatogonial stem cells. ANIMAL REPRODUCTION SCIENCE 151:244-255(2014).
- Berthoud, VM; Minogue, PJ; et al. Connexin50D47A Decreases Levels of Fiber Cell Connexins and Impairs Lens Fiber Cell Differentiation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54:7614-7622(2013).
