GDF2
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Official Full Name
growth differentiation factor 2 -
Overview
Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily. GDF2 has a role in inducing and maintaining the ability of embryonic basal forebrain cholinergic neurons (BFCN) to respond to a neurotransmitter called acetylcholine; BFCN are important for the processes of learning, memory and attention.[2] GDF2 is also important for the maturation of BFCN. Another role of GDF2 has been recently suggested. GDF2 is a potent inducer of hepcidin (a cationic peptide that has a antimicrobial properties) in liver cells (hepatocytes) and can regulate iron metabolism.[3] The physiological receptor of GDF2 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family. GDF2 is one of the most potent BMPs to induce orthotopic bone formation in vivo. BMP3, a blocker of most BMPs seems not to affect GDF2. -
Synonyms
BMP-9;BMP9;GDF2;growth differentiation factor 2;GDF-2;bone morphogenetic protein 9;growth/differentiation factor 2;Human BMP9 ELISA KIT;Human;BMP9 ELISA KIT;ELISA KIT;BMP9 ELISA;KIT;ELISA
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rat
- E.coli
- CHO
- Mammalian Cell
- HEK293
- Mammalian cells
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GDF2 involved in several pathways and played different roles in them. We selected most pathways GDF2 participated on our site, such as ALK1 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ALK1 signaling events | CSNK2B,FKBP1A,ACVRL1 |
Protein Function
GDF2 has several biochemical functions, for example, cytokine activity,growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF2 itself. We selected most functions GDF2 had, and list some proteins which have the same functions with GDF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DTNBP1,CASQ2,FBXO45,GCA,LIN9,SERP2,OSR2,LPAR1,NRP1,TEAD3 |
| cytokine activity | NDR1,IL36G,IFNPHI4,IL4,BMP5,IFNW1,INHBAB,IL18,GM13287,IFNA4 |
| growth factor activity | FGF1B,PDGFB,Il2,IL8L2,IL11,NODAL,BMP2B,GH1,HGF,PRL2C3 |
| transforming growth factor beta receptor binding | GDF5,SMAD2,BMP10,MSTNB,LRG1,FKBP1A,INHBE,LFT1,BMP3,LEFTY2 |
Interacting Protein
GDF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF2.
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References
- Srinivasan, C; Siddiqui, A; et al. Stability characterization and appearance of particulates in a lyophilized formulation of a model peptide hormone-human secretin. INTERNATIONAL JOURNAL OF PHARMACEUTICS 481:104-113(2015).
- Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).
