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FYN

  • Official Full Name

    FYN oncogene related to SRC, FGR, YES

  • Overview

    This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase;that has been implicated in the control of cell growth. The protein associates with the p85 subunit of;phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants;encoding distinct isoforms exist.

  • Synonyms

    FYN;FYN oncogene related to SRC, FGR, YES;tyrosine-protein kinase Fyn;MGC45350;SLK;SYN;src-like kinase;proto-oncogene Syn;c-syn protooncogene;proto-oncogene c-Fyn;src/yes-related novel;tyrosine kinase p59fyn(T);OKT3-induced calcium influx regu

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Chicken
  • E.coli
  • Mammalian cells
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • HEK293
  • HEK293T
  • Wheat Germ
  • In Vitro Cell Free System
  • Insect (sf21)
  • His
  • Flag
  • Non
  • GST
  • Myc&DDK
  • His&T7
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
FYN-0397H Recombinant Human FYN protein, His-tagged E.coli Human His 231-483 aa
FYN-822HFL Active Recombinant Full Length Human FYN Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
FYN-2128H Recombinant Human FYN Oncogene Related To SRC, FGR, YES, His-tagged Insect Cell Human His Full L.
FYN-217H Recombinant Human FYN Oncogene Related To SRC, FGR, YES E.coli Human Non
FYN-2410H Recombinant Human FYN, GST-tagged E.coli Human GST 23-216 a.a.
FYN-2427R Recombinant Rat FYN Protein Mammalian Cell Rat His
FYN-28958TH Recombinant Human FYN Human Non Full L.
FYN-322H Recombinant Human FYN, GST-tagged, Active Sf9 Insect Cell Human GST
FYN-50H Recombinant Human FYN protein, Flag-tagged, Biotinylated Insect Cell Human Flag 1-537 a.a.
FYN-6112M Recombinant Mouse FYN Protein Mammalian Cell Mouse His
FYN-6901C Recombinant Chicken FYN Mammalian Cell Chicken His
FYN-6091HCL Recombinant Human FYN 293 Cell Lysate HEK293 Human Non
FYN-1388H Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
FYN-1766H Recombinant Human FYN protein, His & T7-tagged E.coli Human His&T7 Gly2~Leu537
FYN-2083R Recombinant Rat FYN Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
FYN-2083R-B Recombinant Rat FYN Protein Pre-coupled Magnetic Beads HEK293 Rat
Fyn-3119M Recombinant Mouse Fyn Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
FYN-3213H Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
FYN-3407M Recombinant Mouse FYN Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
FYN-3407M-B Recombinant Mouse FYN Protein Pre-coupled Magnetic Beads HEK293 Mouse
FYN-420H Recombinant Human FYN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
FYN-4585H Active Recombinant Human FYN Protein, GST/His-tagged Insect Cell Human His&GST
FYN-4586H Recombinant Human FYN Protein, GST-tagged Wheat Germ Human GST
FYN-5284HF Recombinant Full Length Human FYN Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 482 amino acids
FYN-5832HF Active Recombinant Full Length Human FYN Protein, DDK-tagged, Biotinylated Insect (sf21) Human Flag Full L. 1-537(end)
FYN-7192HF Active Recombinant Full Length Human FYN Protein, GST-tagged Insect (sf21) Human GST Full L. 1-534(end)
FYN-8109HF Active Recombinant Full Length Human FYN Protein, GST-tagged Insect (sf21) Human GST Full L. 1-537(end)
FYN-949H Recombinant Human FYN Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
FYN-949H-B Recombinant Human FYN Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    FYN involved in several pathways and played different roles in them. We selected most pathways FYN participated on our site, such as Sphingolipid signaling pathway,Phospholipase D signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Osteoclast differentiation STAT1,RAC1,NCF1,TGFBR1,TEC,TNFRSF1A,LILRB4,LILRB1,MAPK1,FCGR3A
    Measles STAT1,IRF3,TYK2,HSPA6,EIF2AK3,STAT5A,IFNA16,CD46,EIF2AK2,OAS1A
    T cell receptor signaling pathway MAPK13,NRAS,NFKB1,MAP2K2,LAT,CD8B,IL5,SOS1,PPP3R1,NCK1
    Sphingolipid signaling pathway TNFRSF1A,PRKCE,SPTLC1,SGPP2,ROCK1,DEGS1,PPP2R1A,RELA,LASS4,PPP2R3A
    Axon guidance CLTC,HFE2,NRG2A,LAMTOR2,PAQR3A,TRPC5,EPHB6,NTN1A,NRP1,AP2S1
    Viral myocarditis ITGB2,SGCD,HLA-DOB,CASP8,HLA-DRB5,HLA-DRB1,CXADR,HLA-DRA,HLA-E,HLA-DQA2
    Platelet activation RHOA,ITPR3,TBXAS1,GNAI2,PLA2G4A,P2RY12,PRKG1,PRKACG,ITPR1,GP6
    Phospholipase D signaling pathway MAP2K2,RHOA,PIK3R5,PIK3R1,RRAS2,ARF6,SYK,SHC2,F2R,CYTH2
    Prion diseases HSPA5,C1QC,PRKACG,MAPK1,C9,IL1A,LAMC1,PRKACA,STIP1,C5

    Protein Function

    FYN has several biochemical functions, for example, ATP binding,CD4 receptor binding,CD8 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FYN itself. We selected most functions FYN had, and list some proteins which have the same functions with FYN. You can find most of the proteins on our site.

    Function Related Protein
    protein binding MEI4,GADD45G,ROBO2,ZP3,ZNF496,FBXO2,NTHL1,NCL,DERL2,TUBGCP2
    phosphatidylinositol 3-kinase binding LCK,DAB1,IRS1,IGF1RA,INSRA,IRS2,CALM2,ATP1A1,HCST,INSR
    glycoprotein binding Shh,CALR,IDE,RGMA,FBXO2,Itgam&Itgb2,ERBB2,OS9,FBXO6,SDCBP
    protein tyrosine kinase activity IGF1RA,AXL,TYK2,EGFRA,MET,BLK,DSTYK,WEE2,MUSK,DYRK1A
    tubulin binding ALDOA,STMN4,PARK2,RITA1,IFT81,VBP1,STMN1A,MAP1S,BIRC5,AGBL1
    T cell receptor binding CD1d1,H2-Q10,DOCK2,CD3E,EPS8L1,HLA-A,CD3G
    metal ion binding FGD3,PLA2G2F,EXOG,MOB1A,CRYAB,NOS2B,PON2,PRKCE,NRXN2A,ZFP93
    CD8 receptor binding LCK
    ephrin receptor binding Anks1,EFNA3,EFNA5,EFNB2A,EFNB3B,PIK3CG,SHC1,NTRK1,EFNB2B,EFNA1B

    Interacting Protein

    FYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FYN here. Most of them are supplied by our site. Hope this information will be useful for your research of FYN.

    FYB;CBL;PRKCD;KHDRBS1

    Resources

    Gene Families

    What Is Tumor Necrosis Factor (TNF)/TNF Superfamily

    Research Area

    Histone Phosphorylation
    Synaptic Proteins
    Intracellular Kinases in the Akt Pathway
    Src Kinases
    Negative Regulators of the Jak/STAT Pathway
    Intracellular Signaling Molecules in Angiogenesis
    Natural Killer T (NKT) Cells
    B Cell Receptor-Associated Proteins

    References

    • Nisbet, RM; Polanco, JC; et al. Tau aggregation and its interplay with amyloid-beta. ACTA NEUROPATHOLOGICA 129:207-220(2015).
    • Gujral, TS; Chan, M; et al. A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. CELL 159:844-856(2014).

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