FXYD3
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Official Full Name
FXYD domain containing ion transport regulator 3 -
Overview
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
FXYD3;FXYD domain containing ion transport regulator 3;FXYD domain containing ion transport regulator 3 , PLML;FXYD domain-containing ion transport regulator 3;MAT 8;Chloride conductance inducer protein Mat 8;Chloride conductance inducer protein Mat-8;FXYD3_HUMAN;Mammary tumor 8 kDa protein;MAT-8;MAT8;MGC111076;Phospholemman like;Phospholemman-like;PLML;phospholemman-like protein
Recombinant Proteins
- Human
- Rat
- Mouse
- Sus scrofa (Pig)
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- His
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- GST
Involved Pathway
FXYD3 involved in several pathways and played different roles in them. We selected most pathways FXYD3 participated on our site, such as Ion channel transport,Ion transport by P-type ATPases,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXYD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ion transport by P-type ATPases | ATP1A1A.3,ATP8B1,ATP2C1,ATP13A5,ATP2B1B,ATP10A,FXYD6,ATP2B3A,CUTC,ATP1A1A.2 |
| Transmembrane transport of small molecules | SLC38A3A,SLC26A3,SLC5A4,SLC7A3,CTNS,WNK1,ATP1A1A.4,MYO5B,CLCN5,RHCG2A |
| Ion channel transport | ASPH,CUTC,CLCN6,ATP7B,GSDMA2,TRPA1A,ANO9,ATP2B1B,TRDN,CLCN1 |
Protein Function
FXYD3 has several biochemical functions, for example, ATPase binding,chloride channel activity,sodium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FXYD3 itself. We selected most functions FXYD3 had, and list some proteins which have the same functions with FXYD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chloride channel activity | SLC26A11,TTYH2,CLCN5,GABRE,SLC26A4,GABRB2,CLCA5,GABRP,APOL1,SLC1A4 |
| ATPase binding | ATP6V0A1B,FXYD7,SYVN1,SVIP,ATXN3,NR1H2,ANK2,ATP1B1,SELS,ATP6V0A4 |
| sodium channel regulator activity | SGK1,YWHAH,RANGRF,TMPRSS3,FXYD2,SCN1BB,GPLD1,SGK2,FGF12,NEDD4L |
Interacting Protein
FXYD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXYD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXYD3.
CREB3;NUDT3;NR4A1;MAPK6;q5vu21_human;CREB3L1;FBXL12
Resources
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References
- Vallois, D; Niederhauser, G; et al. Gluco-Incretins Regulate Beta-Cell Glucose Competence by Epigenetic Silencing of Fxyd3 Expression (vol 9, e103277, 2014). PLOS ONE 9:-(2014).
- Li, YF; Zhang, X; et al. Expression and clinical significance of FXYD3 in endometrial cancer. ONCOLOGY LETTERS 8:517-522(2014).
