FUT9
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Official Full Name
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) [ Homo sapiens ] -
Overview
The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. -
Synonyms
Fut9;mFUT9;AI746471;AU067636;mFuc-TIX;alpha-(1,3)-fucosyltransferase 9;fuc-TIX;fucT-IX;fucosyltransferase IX;galactoside 3-L-fucosyltransferase
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Chicken
- Mus musculus
- E.coli
- CHO
- Mammalian Cell
- HEK293
- E.Coli or Yeast
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- His&GFP
Involved Pathway
FUT9 involved in several pathways and played different roles in them. We selected most pathways FUT9 participated on our site, such as Glycosphingolipid biosynthesis - globo series,Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| terminal O-glycans residues modification | GCNT3 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | GGTA1,ST3GAL3,ST3GAL4,B3GNTL2,FUT1,FUT3,ST3GAL3B,B3GNT5A,FUT6,B3GALT1 |
| Other types of O-glycan biosynthesis | B3GALTLA,B4GALT1,FUT9A,B3GAT1A,LFNG,RFNG,B3GALTL,POMT2,GXYLT2,ST3GAL3 |
| Metabolic pathways | CYP2C19,PNP5A,Ckmm,CHSY3,RDH11,NT5C2A,CRYL1,GFPT1,CYP27B1,GM5506 |
| Glycosphingolipid biosynthesis - globo series | FUT9A,ST3GAL1,GLA,FUT1,GBGT1,ST3GAL2,NAGA,B3GALT5,A4GALT,HEXB |
Protein Function
FUT9 has several biochemical functions, for example, alpha-(1->3)-fucosyltransferase activity,fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT9 itself. We selected most functions FUT9 had, and list some proteins which have the same functions with FUT9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-(1->3)-fucosyltransferase activity | FUT11,GALNTL4,FUT6,FUT4,PIGB,B3GNTL1,GALNT18A,FUT3,FUT7,POC1BL |
| fucosyltransferase activity | POC1BL,B3GNT9-PS,DPY19L1,GLT8D1,POMGNT2,4931440L10Rik,FUT7,GTDC2,FUT9A,FUT6 |
Interacting Protein
FUT9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT9 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT9.
ZDHHC17;TSSK3
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References
- Itokazu, Y; Yu, RK; et al. Amyloid beta-Peptide 1-42 Modulates the Proliferation of Mouse Neural Stem Cells: Upregulation of Fucosyltransferase IX and Notch Signaling. MOLECULAR NEUROBIOLOGY 50:186-196(2014).
- Li, J; Yang, J; et al. Efficient Generalized Least Squares Method for Mixed Population and Family-based Samples in Genome-wide Association Studies. GENETIC EPIDEMIOLOGY 38:430-438(2014).
