FOXP3
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Official Full Name
forkhead box P3 -
Overview
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
FOXP3;forkhead box P3;JM2;AIID;IPEX;PIDX;XPID;DIETER;forkhead box protein P3;scurfin;FOXP3delta7;immunodeficiency, polyendocrinopathy, enteropathy, X-linked;immune dysregulation, polyendocrinopathy, enteropathy, X-linked
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- His&GST
- Myc&DDK
- Non
- Flag
- N-His&C-Myc
- His&Fc&Avi
Involved Pathway
FOXP3 involved in several pathways and played different roles in them. We selected most pathways FOXP3 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory bowel disease (IBD) | IL1B,TGFB3,HLA-DQB1,Il2,HLA-DRB3,STAT6,IL18,IL12B,IL6,IL18RAP |
Protein Function
FOXP3 has several biochemical functions, for example, NF-kappaB binding,NFAT protein binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXP3 itself. We selected most functions FOXP3 had, and list some proteins which have the same functions with FOXP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SOX17,HNF1B,GATA4,ZFHX3,SOX10,GTF2IRD1,SRY,MEF2A,NKX2,RFX1 |
| histone acetyltransferase binding | EPAS1,TRIM68,EGR1,EID1,ZBTB7A,TRIP4,PAX6,TRP53,HIF1A,KAT2B |
| histone deacetylase binding | RELA,KPNA2,ZMYND15,D7ERTD443E,NR2C1,HIC1,MAGEA2B,PRDM1,RUNX2,TAL1 |
| sequence-specific DNA binding | ISL2,LHX8,EVX2,PBX2,ENG2B,ETV5A,SIX4,INSM1A,FOXO3A,EVE1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | SP2,FOXO3,ETV2,ELK4,JUN,FOXJ1A,FLI1B,MITFB,ATF4,NHLH2 |
| core promoter binding | NKX3,GATA1,PYDC3,AGO2,KDM3A,IRF9,EP300,CRY1,KLF4,GADD45A |
| protein homodimerization activity | PRMT2,E2F8,GDNF,CACYBP,MITD1,MGST1,GSTM1,MTERFD3,GRIK1,ERCC5 |
| transcription corepressor activity | HOMEZA,MYBBP1A,RBFOX2,MECP2,KLF12,E2F7,PAWR,JUB,ATF3,LOXL2 |
| transcription factor activity, sequence-specific DNA binding | HLF,TBPL2,SNAPC2,TA,NME2,RARAA,SALL3B,CHES1,FOXG1C,TCF7 |
Interacting Protein
FOXP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXP3.
PRR20C;RBPMS;IKZF3;mouse_arre2_site_il2_promoter_1;HDAC7;IKZF3;HDAC9;arre2_element_mouse_il2_promoter;Ctla4;il2ra_mouse_gene;Il2;RORC
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References
- Martinson, HA; Jindal, S; et al. Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression. INTERNATIONAL JOURNAL OF CANCER 136:1803-1813(2015).
- Kaser, T; Mair, KH; et al. Natural and inducible Tregs in swine: Helios expression and functional properties. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 49:323-331(2015).
