FOXA3
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Official Full Name
forkhead box A3 -
Overview
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are;transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact;with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation;of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. -
Synonyms
FOXA3;forkhead box A3;hepatocyte nuclear factor 3-gamma;FKHH3;Fork head-related protein FKH H3;Forkhead box protein A3;FOXA3_HUMAN;hepatic nuclear factor-3-beta;hepatocyte nuclear factor 3;hepatocyte nuclear factor 3 gamma;HNF-3-gamma;HNF-3G;HNF3B;HNF3G;TCF-3G;TCF3G;Transcription factor 3G;hepatocyte nuclear factor 3 gamma (winged helix transcription factor)
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Arg
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
FOXA3 involved in several pathways and played different roles in them. We selected most pathways FOXA3 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | INS,MAFA,HNF1B,HHEX,PDX1,PKLR,HNF1A,INS1,HNF4A,NKX6-1 |
Protein Function
FOXA3 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding,protein domain specific binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXA3 itself. We selected most functions FOXA3 had, and list some proteins which have the same functions with FOXA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | Ar,CTNNB1,NKX3-1,SERPINB1A,ZNF174,RCOR1,SMAD7,DDIT3,SALL3B,ZNF567 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXQ2,FOXC1B,ZNF496,FOXI2,NPAS1,NFIB,FOXG1D,FOXO3B,CC2D1A,SIM1A |
| transcription factor activity, sequence-specific DNA binding | GATA5,ZNF232,CEBPA,MYC,ZFY2,HIRA,ZNF621,ZNF287,GRHL2,NFE2L2A |
| transcription factor binding | PIAS1,HES3,Trl,PAX2,MYOD1,TAF7,MYOCD,ARNT,NKX3-1,PIK3R1 |
| sequence-specific DNA binding | NLRP3,PRRX1B,DBX1,LHX6,HIC1,HLX1,ALX4B,TFCP2L1,DLX4,FOXM1 |
| protein domain specific binding | TWIST1,TH,PLXND1,SORBS2,SKI,TACC2,NDE1,HIST1H4J,ARFIP2B,CALM1 |
Interacting Protein
FOXA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXA3.
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References
- Koh, KH; Pan, X; et al. Kruppel-Like Factor 9 Promotes Hepatic Cytochrome P450 2D6 Expression during Pregnancy in CYP2D6-Humanized Mice. MOLECULAR PHARMACOLOGY 86:727-735(2014).
- Ma, XR; Xu, LY; et al. Role of forkhead box protein A3 in age-associated metabolic decline. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:14289-14294(2014).
