FOSL1
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Official Full Name
Fos-related antigen 1 -
Overview
Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. -
Synonyms
FLJ23306;Fos L2;FOS like antigen 2;Fos related antigen 2;Fos-related antigen 2;FosL 2;Fosl2;FOSL2;FRA 2;FRA-2;Fos-related antigen 1;FOSL1;FRA;FRA1;fra-1
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Sf21 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- Non
- His
- Myc&DDK
- His&T7
- His&GST
- His&Fc&Avi
- Flag
Involved Pathway
FOSL1 involved in several pathways and played different roles in them. We selected most pathways FOSL1 participated on our site, such as Wnt signaling pathway,Osteoclast differentiation,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | CYLD,SIRPB1,CSF1,MAPK9,GRB2,NCF4,IKBKG,SOCS1,PPP3CC,MAPK1 |
| HTLV-I infection | TGFB2,RB1,IL2RB,ZFP36,SLC2A1,MRAS,POLE3,POLD2,WNT2,MAP3K3 |
| Wnt signaling pathway | PPP3CC,PRKCBB,WNT7B,CXXC4,PRKACBB,SFRP1A,SFRP5,WNT11R,DAAM2,NFATC3 |
Protein Function
FOSL1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOSL1 itself. We selected most functions FOSL1 had, and list some proteins which have the same functions with FOSL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZRANB2,NEUROG1,NR4A2B,FOXD1L,ZNF215,IRF4,STAT5A,ZNF41,ZNF454,ZNF544 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MYOG,HMGA2,MITFB,FOXD1,OTX2,CAMTA2,NFATC3,MYBL2,EHF,ETV2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | IFI203,TBP,ATF7,MYF5,TLX1,MSX2,TFE3A,NEUROD1,YBX1,FIGLA |
| protein binding | PTPLAD1,TAB1,GDF7,THAP3,MBD3,COA3,FAM120B,ABI3,RAB2B,TCF12 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | RBPJA,ARNTL2,RBPJL,RBPJB,BATF2,FOSL1A,ARNTL,MSX2,CREB3,SFPI1 |
Interacting Protein
FOSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOSL1.
NME7;LDOC1;JUN;USF1;CREB5
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References
- Bian, YS; Han, JW; et al. MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 11:411-422(2015).
- Delgado-Olguin, P; Dang, LT; et al. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. DEVELOPMENT 141:4610-4617(2014).
