FLI1
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Official Full Name
Friend leukemia virus integration 1 -
Overview
ETS-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. This family of genes currently includes ETS-1, ETS-2, ERG-1, ERG-2, ELK, E74, FLI-1, PU.1 and PEA3. Members of the ETS gene family exhibit varied pattern of tissue expression, and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. -
Synonyms
FLI1;Friend leukemia virus integration 1;Friend leukemia integration 1 transcription factor;EWSR2;SIC 1;proto-oncogene Fli-1;transcription factor ERGB;SIC-1
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
FLI1 involved in several pathways and played different roles in them. We selected most pathways FLI1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | CEBPE,CDK14,Pdgfa&Pdgfb,IL6,RELA,HDAC1,PLAT,LMO2,TLX1,ETV4 |
Protein Function
FLI1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLI1 itself. We selected most functions FLI1 had, and list some proteins which have the same functions with FLI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM126B,HNRNPUL1,SYT4,SPOP,IREB2,PMM2,RYK,DHX38,HSPB11,ZBTB48 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MEOX2,ZFP750,SMAD2,NDN,ETV6,MYOCD,ZIC1,TCF21,JUN,CEBPB |
| transcription factor activity, sequence-specific DNA binding | EGR3,BHLHE22,ELK1,FOXD4,NEUROD2,GATA2A,ZFY2,NR3C1,FOXC1B,NR1I3 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ELF3,FOXI1,RBPJA,GLI2,PITX1,FEZF2,ZBTB7A,HELT,POU4F2,ZNF664 |
| DNA binding | TRIM21,KIAA0020,HMGXB4,TNP2,JUNBA,LYL1,ZFP292,HOXB6A,FBXL19,PDCD5 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | MIXL1,HNRNPC,TAL1,PROP1,RXRB,NFE2L1,BACH1,MED12,TFAP2C,BACH2 |
| chromatin binding | HMGB1A,CBX5,JUB,ATXN7,MSGN1,CAMTA2,NSD1,SLC30A9,PAX3,NEUROD1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXD2,CC2D1B,MAZ,ETS1,ZNF18,TWIST1,HOXA13B,FOXQ2,LYL1,NPAS4A |
Interacting Protein
FLI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLI1.
SOX30;SIAH1;CTBP2;Grip1;SP100;SMAD9;ilvD
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References
- Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
- Shibuya, R; Matsuyama, A; et al. The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma. VIRCHOWS ARCHIV 465:599-605(2014).
