FKBP2
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Official Full Name
FK506 binding protein 2, 13kDa -
Overview
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
FKBP2;FK506 binding protein 2, 13kDa;FK506 binding protein 2 (13kD);peptidyl-prolyl cis-trans isomerase FKBP2;FKBP 13;peptidyl prolyl cis trans isomerase;PPIase;proline isomerase;rapamycin binding protein;13 kDa FK506-binding protein;13 kDa FKBP;EC 5.2.1.8;FK506 binding protein 2 13kDa;FK506-binding protein 2;FKBP 2;FKBP-13;FKBP-2;FKBP13;FKBP2_HUMAN;Immunophilin FKBP13;PPIase FKBP2;Rotamase;OTTHUMP00000236930;OTTHUMP00000236931;OTTHUMP00000236933;rapamycin-binding protein;FK506-binding protein 2 (13kD)
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- Rhizopus delemar
- Human
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- Non
- His
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FKBP2 involved in several pathways and played different roles in them. We selected most pathways FKBP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FKBP2 has several biochemical functions, for example, FK506 binding,peptidyl-prolyl cis-trans isomerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP2 itself. We selected most functions FKBP2 had, and list some proteins which have the same functions with FKBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidyl-prolyl cis-trans isomerase activity | PPIL2,PPIAL4C,PPIAL4B,PPIF,FKBP8,FKBP14,FKBP10,PPIFA,RANBP2,PPIH |
| protein binding | ARHGDIA,BANP,TUFM,AAGAB,C1S,BCAP31,HEMK1,BSCL2,NTSR1,DSCAM |
| FK506 binding | FKBP1AB,FKBP14,FKBP1AA,FKBP11,FKBP1B,FKBP10B,FKBP4,FKBPL,FKBP7,FKBP10 |
Interacting Protein
FKBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP2.
UBQLN1;UBQLN1;UBQLN4;Pdia3;RAP2A;MAPK3;BAG6;yvaE
Resources
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References
- Borsy, A; Podani, J; et al. Identifying novel genes involved in both deer physiological and human pathological osteoporosis. MOLECULAR GENETICS AND GENOMICS 281:301-313(2009).
- Cole, JB; Wiggans, GR; et al. Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary US Holstein cows. BMC GENOMICS 12:-(2011).
