FKBP1B
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Official Full Name
FK506 binding protein 1B, 12.6 kDa -
Overview
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. -
Synonyms
FKBP1B;FK506 binding protein 1B, 12.6 kDa;FK506 binding protein 1B (12.6 kD) , FKBP1L;peptidyl-prolyl cis-trans isomerase FKBP1B;FKBP9;FKBP12.6;OTK4;PPIase;12.6 kDa FK506-binding protein;12.6 kDa FKBP;Calstabin 2;FK506 binding protein 1 like;FK506 binding protein 12.6;FK506 binding protein 1B 12.6 kDa;FK506 binding protein 1B;FK506-binding protein 1B;FKB1B_HUMAN;FKBP 12.6;FKBP 1B;FKBP 1L;FKBP 9;FKBP-12.6;FKBP-1B;FKBP1L;h FKBP 12;h-FKBP-12;Immunophilin FKBP12.6;OTK 4;Peptidyl prolyl cis trans isomerase 1B;Peptidyl prolyl cis trans isomerase;PKBP 1L;PKBP1L;PPIase 1B;PPIase FKBP1B;Rotamase 1B;Rotamase;OTTHUMP00000116040;OTTHUMP00000116041;FK506-binding protein 12.6;12.6 kDa FK506-binding
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Cattle
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
FKBP1B involved in several pathways and played different roles in them. We selected most pathways FKBP1B participated on our site, such as Integrated Pancreatic Cancer Pathway,Ion channel transport,Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stimuli-sensing channels | MCOLN2,UNC79,MCOLN3,TRPC4A,TRPM6,GSDMA2,ANO10A,ANO1,TSC22D3,SRI |
| Integrated Pancreatic Cancer Pathway | FKBP3,FST,MAPK4,CASP12,CD82,IL11,BRF1,TOP2A,AGA,TFF1 |
| Transmembrane transport of small molecules | AQP11,SLC5A2,FXYD3,CLCN2,SLC35A2,SLC9A9,CLCN1,WNK2,WNK1,ABCG2D |
| Ion channel transport | CLCN1A,ATP7B,TTYH1,TPCN1,WNK1,CCC2,CLCNKA,BEST4,TRPC4,ANO10 |
Protein Function
FKBP1B has several biochemical functions, for example, FK506 binding,calcium channel inhibitor activity,cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP1B itself. We selected most functions FKBP1B had, and list some proteins which have the same functions with FKBP1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptidyl-prolyl cis-trans isomerase activity | FKBP4,FKBPL,PPIAA,FKBP1A,PIN1,FKBP3,FKBP7,PPIA,PPIFB,FKBP1AA |
| ion channel binding | CALM2,KCNJ11,FHL1,SLC8A1,CAV3,TRPC1,BAK1,PKP2,NOS1,CTNNB1 |
| protein binding | LPL,EXD1,CD47,BEGAIN,LDB1,ATG5,SLC52A2,STK40,AIP,CYBRD1 |
| cyclic nucleotide binding | CNP |
| receptor binding | ABL1,CAT,FYNA,HAO2,PANX1,BMP3,MIF,SLC39A1,LBP,CNPY3 |
| calcium channel inhibitor activity | STX1A,ITPR1,FKBP1AB,SLC30A1A,PHPT1,FKBP1AA,PACSIN3,AMBP,SLC30A1B,CCDC109B |
| FK506 binding | FKBP7,TTC9B,FKBP14,TTC9C,FKBP9,FKBP6,FKBP4,FKBP1A,FKBP10B,FKBP1AB |
Interacting Protein
FKBP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP1B.
RYR2;REL;CAMK2D;KRT31;FLJ13057;KRT40
Resources
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References
- Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).
- Francia, P; Adduci, C; et al. Common genetic variants in selected Ca2+ signaling genes and the risk of appropriate ICD interventions in patients with heart failure. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY 38:169-177(2013).
