FKBP1A
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Official Full Name
FK506 binding protein 1A, 12kDa -
Overview
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008] -
Synonyms
FKBP1A;FK506 binding protein 1A, 12kDa;FKBP1;PKC12;PKCI2;FKBP12;PPIASE;FKBP-12;FKBP-1A;peptidyl-prolyl cis-trans isomerase FKBP1A;rotamase;12 kDa FKBP;calstabin 1;calstabin-1;FKBP12-Exip3;PPIase FKBP1A;immunophilin FKBP12;FK506 binding protein12;FK506-binding protein 1;FK506-binding protein 12;12 kDa FK506-binding protein;protein kinase C inhibitor 2;FK506-binding protein 1A (12kD);FK506-binding protein, T-cell, 12-kD
Recombinant Proteins
- Mouse
- Human
- Cattle
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- E. coli
- His
- Non
- GST
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
FKBP1A involved in several pathways and played different roles in them. We selected most pathways FKBP1A participated on our site, such as ALK1 pathway,ALK1 signaling events,ALK2 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diseases of signal transduction | HDAC5,MIB1,CDK8,MYO18A,CUX1,JAG2,CCNC,LRRFIP1,CTBP2,CDC37 |
| Calcium signaling in the CD4+ TCR pathway | RCAN2,AKAP5,JUNB,BATF3,POU2F1,CHP,CSF2,RCAN1 |
| Alpha-synuclein signaling | CSNK2A1,STUB1,PARK7,TOR1A,KLK6,BLK |
| Disease | OPN1LW,AP2B1,APOBEC3G,AMN,KREMEN1,CTDP1,JAG2,TICAM1,AP1B1,TCEA1 |
| ALK1 signaling events | CSNK2B,GDF2,ACVRL1 |
| Calcium Regulation in the Cardiac Cell | RGS5A,YWHAQ,RGS10,CHRM3,CASQ1,GJA10,GJB2,CX30.3,GJB1,RGS16 |
| ALK1 pathway | ACVRL1 |
Protein Function
FKBP1A has several biochemical functions, for example, FK506 binding,SMAD binding,activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP1A itself. We selected most functions FKBP1A had, and list some proteins which have the same functions with FKBP1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel binding | PACS2,RYR2,FYN,HSP90AB1,RIMS3,PACS1A,CAMK2D,KCNH1,USP10,ARRB1 |
| protein binding | TMA16,TNP1,ANGPT1,ZCCHC7,MYH8,RAD51C,CLOCK,CCND2,NSMCE2,CAB39 |
| SMAD binding | EP300,TGFBR1,COL1A2,YY1,SKOR1B,STUB1,ACVR1B,SKOR1,SKOR2,TOB1 |
| FK506 binding | FKBP14,FKBP7,TTC9B,FKBP1B,FKBP6,TTC9C,FKBP4,FKBP11,FKBP1AB,FKBP1AA |
| signal transducer activity | HTR5AL,OLFR486,GNGT2,FLNA,TAAR8A,TAS2R138,IRS1,OLFR151,BAI2,OLFR49 |
| activin binding | SMURF1,FST,ACVR1,ACVR2B,ACVRL1,TGFBR3,ENG,SMAD7,FSTL3 |
| transforming growth factor beta receptor binding | NDR1,GDF9,BMP2B,GDF10,GDF3,GDF15,GDF11,BMP7B,GDF2,MSTN |
| type I transforming growth factor beta receptor binding | SMAD7,SMAD2,SNX25,SMAD6,TGFB1,TGFB3,TGFBR2,ENG |
| peptidyl-prolyl cis-trans isomerase activity | PPIB,FKBP10B,FKBP14,FKBP6,FKBP3,PPIFA,PPIC,FKBP7,FKBP4,FKBP8 |
Interacting Protein
FKBP1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP1A here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP1A.
MTOR;RYR1;TGFBR1;SMAD7;AHSP;ACVR1B;sirolimus;ryr1_oncmy_protein;ryr1;EPB41;VHL;FKBP1B
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References
- Gant, JC; Blalock, EM; et al. FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca2+ dysregulation?. EUROPEAN JOURNAL OF PHARMACOLOGY 739:74-82(2014).
- Zhang, YY; Shen, W; et al. Proteomics reveals potential non-neuronal cholinergic receptor-effectors in endothelial cells. ACTA PHARMACOLOGICA SINICA 35:1137-1149(2014).
