FHIT
-
Official Full Name
fragile histidine triad -
Overview
Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. -
Synonyms
FHIT;fragile histidine triad;fragile histidine triad gene;bis(5-adenosyl)-triphosphatase;AP3Aase;FRA3B;AP3A hydrolase;tumor suppressor protein;dinucleosidetriphosphatase;diadenosine 5,5-P1,P3-triphosphate hydrolase
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Rat
- Chicken
- Mouse
- Mammalian Cell
- E.coli
- Human
- HEK293
- Yeast
- HEK293T
- Wheat Germ
- His
- Non
- GST
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FHIT involved in several pathways and played different roles in them. We selected most pathways FHIT participated on our site, such as Purine metabolism,Small cell lung cancer,Non-small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FHIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | POLR1E,PDE7A,NME2B.2,PRIM1,GMPR,PNP5B,PNP5A,Adcy4,PKMA,POLR1A |
| Small cell lung cancer | BCL2,TRAF1,BCL2L1,TRAF6,ITGB1,TRAF2,PIK3CG,CASP9,IKBKG,ITGAV |
| Non-small cell lung cancer | PRKCG,PIK3R5,RXRB,RXRA,CCND1,KRAS,PLCG2,PIK3CB,PIK3CD,PIK3CA |
Protein Function
FHIT has several biochemical functions, for example, bis(5-adenosyl)-triphosphatase activity,catalytic activity,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FHIT itself. We selected most functions FHIT had, and list some proteins which have the same functions with FHIT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | ARRB2,HSPA8,MAGEA2B,NKD2,UCHL1,STX8,DAXX,GLMN,BRCA1,UBE2U |
| nucleotide binding | GATB,CPEB1A,RBM25,RBM8A,SRPK1A,NT5C3A,ENOX1,GRK7B,MXG,UBE2D2A |
| bis(5-adenosyl)-triphosphatase activity | ENPP4 |
| protein binding | ZWINT,RFESD,UBE2B,GIT1,B3GAT3,ADA,PTGDS,MMACHC,ARNT,DHX16 |
| identical protein binding | P2RX6,CLDN15,NUFIP1,GOT1L1,ASS1,DHX8,SMAD3,RBM10,C1QL4,TRIM8 |
| hydrolase activity | PTPN11B,CHD6,IDI2,DAGLB,PTPRU,ELA3L,DDX19,LCTLB,DUSP22B,PPM1NB |
| catalytic activity | GMPR2,ALDOAB,AOAH,AOX3,CKMT2A,PPM1LA,ACSL1B,PNP4A,ACLYA,HADHAB |
Interacting Protein
FHIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FHIT here. Most of them are supplied by our site. Hope this information will be useful for your research of FHIT.
FDXR;HSPE1;HSPD1;ALDH2;ETFB;MDH2
Resources
Related Services
Related Products
References
- Chen, YN; Wang, XL; et al. Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma. ANNALS OF DIAGNOSTIC PATHOLOGY 19:33-36(2015).
- Joannes, A; Grelet, S; et al. Fhit Regulates EMT Targets through an EGFR/Src/ERK/Slug Signaling Axis in Human Bronchial Cells. MOLECULAR CANCER RESEARCH 12:775-783(2014).
