FGF13
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Official Full Name
fibroblast growth factor 13 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5 end results in several transcript variants encoding different isoforms with different N-termini. -
Synonyms
FGF13;fibroblast growth factor 13;FGF2;FHF2;fibroblast growth factor homologous factor 2;FGF 13;FGF 2;FGF-13;FGF13_HUMAN;FHF 2;FHF-2;OTTHUMP00000024143;OTTHUMP00000024144
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
FGF13 involved in several pathways and played different roles in them. We selected most pathways FGF13 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | INS1,SIPA1L1,MAPK12,APBB1IP,MAPK1,GNAI1,FGFR3,ITGB2,FGF11,FLT1 |
| Regulation of Actin Cytoskeleton | ITGA2B,CFL2,PIKFYVE,CYFIP1,PIP5K1BA,ITGB5,ARHGEF7B,PDGFD,SCIN,ACTN4 |
| Ras signaling pathway | RAC3,ELK1,RAP1A,FGF9,IGF1R,HGF,RIN1,PLA2G5,PRKCG,RGL2 |
| MAPK signaling pathway | MAP3K5,CACNB4A,MAPKAPK3,PTPN7,FGF1,PPP3R1B,RAC3,CDC25B,RASGRF2,FGF13A |
| Pathways in cancer | BDKRB1,FGF19,XIAP,PTGS2,MAX,PLCB4,CCND1,MITF,RB1,LPAR6 |
| PIK-Akt signaling pathway | PPP2R5E,HSP90AA1,PIK3R2,TCL1B4,GH2,BAD,GH1,AKT1,FGF18,INS2 |
| Melanoma | PIK3R2,ARAF,PIK3R5,FGF8,PIK3CD,PIK3CG,FGF14,AKT1,FGF20,TRP53 |
Protein Function
FGF13 has several biochemical functions, for example, beta-tubulin binding,growth factor activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF13 itself. We selected most functions FGF13 had, and list some proteins which have the same functions with FGF13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel binding | PKD2,PKP2,ACTN4,PDE4B,FYN,RYR2,HOMER1,FGF12,TRPC1,CALM3 |
| growth factor activity | FGF8B,IGF2A,CLCF1,VEGFAB,MIA1,KLK1B4,MIA,GDNFA,EPGN,REG1A |
| protein kinase activator activity | NKX3-1,DBF4B,TOM1L1,FAM58A,PRKAG2,NCKAP1L,CAB39,EPO,DAXX,MARK2 |
| microtubule binding | RGS14,NUMA1,MID1,KATNA1,MAP1LC3C,MAP205,CRYAB,NEFM,KIF19,TRAF3IP1 |
| sodium channel regulator activity | GPLD1,PRSS30,FXYD1,SCN1BB,SCN2B,SGK1,CAV3,YWHAH,SGK3,NOS1 |
| protein binding | RB1CC1,RABGAP1,PPP1R7,SLC9A1,TDRD7,TSSK2,HOOK2,CENPT,BET1,OSBPL2 |
| beta-tubulin binding | OST4,ARL8A,SIRT2,PDCD5,ARL8B,PACRG,BBS4,GABARAP,RANBP10,PIFO |
Interacting Protein
FGF13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF13 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF13.
PRNP;CLEC3B;MAPK8IP2
FGF13 Related Signal Pathway
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References
- Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
- Tyler, CR; Allan, AM; et al. Prenatal alcohol exposure alters expression of neurogenesis-related genes in an ex vivo cell culture model. ALCOHOL 48:483-492(2014).
