FCAR
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Official Full Name
Fc fragment of IgA, receptor for -
Overview
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
FCAR;Fc fragment of IgA, receptor for;immunoglobulin alpha Fc receptor;CD89;Fc alpha receptor;FCAR_HUMAN;IgA Fc receptor;OTTHUMP00000068691;OTTHUMP00000068692;OTTHUMP00000068693;OTTHUMP00000068694;OTTHUMP00000068695;OTTHUMP00000068696;OTTHUMP00000068697;OTTHUMP00000068698
Recombinant Proteins
- Rat
- Human
- HEK293
- E.coli
- Wheat Germ
- Human Cell
- Human Cells
- Insect Cell
- HEK293T
- Mammalian cells
- E.coli expression system
- His
- Non
- GST
- His&GST
- His&T7
- His&Fc
- Myc&DDK
- Fc
Involved Pathway
FCAR involved in several pathways and played different roles in them. We selected most pathways FCAR participated on our site, such as Phagosome,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ATP6V1AA,ACTB2,ITGAV,ATP6V0E,TUBB,ITGAM,TLR4BA,RILP,C3,RAB5AB |
| Staphylococcus aureus infection | HLA-DOA,cgr2b,FCGR3A,FCGR3B,HLA-DRB3,FPR2,HLA-DMB,FCGR2B,ITGAM,HLA-DQA1 |
Protein Function
FCAR has several biochemical functions, for example, IgA binding,receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FCAR itself. We selected most functions FCAR had, and list some proteins which have the same functions with FCAR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| IgA binding | AMBP,IGJ,FCAMR |
| receptor signaling protein activity | DOK4,PLCG1,ADCYAP1,RAF1B,TYROBP,FCGR1A,IFITM1,cgr2b,TRAIP,GNAZ |
Interacting Protein
FCAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCAR here. Most of them are supplied by our site. Hope this information will be useful for your research of FCAR.
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References
