EWSR1
-
Official Full Name
Ewing sarcoma breakpoint region 1 -
Overview
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. -
Synonyms
EWSR1;Ewing sarcoma breakpoint region 1;RNA-binding protein EWS;EWS;Ewings sarcoma EWS-Fli1 (type 1) oncogene;bK984G1.4
Recombinant Proteins
- Rhesus macaque
- Human
- Chicken
- Cynomolgus
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E. coli
- Mammalian cells
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
EWSR1 involved in several pathways and played different roles in them. We selected most pathways EWSR1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EWSR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | CDK14,KDM6A,TLX3,SUPT3H,ATM,HIST1H3H,FLI1,HIST1H3G,FUT8,MLLT3 |
Protein Function
EWSR1 has several biochemical functions, for example, RNA binding,calmodulin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EWSR1 itself. We selected most functions EWSR1 had, and list some proteins which have the same functions with EWSR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | RBMX,RASL10B,RABL6,EK1,HDGF,TMEM63B,ABCB6,ATP1A1A.4,GM4922,NXF3 |
| RNA binding | MKI67IP,U2AF2A,CPEB3,RPL3,IFIT10,EIF4E3,DOM3Z,RALY,SRBD1,SRP14 |
| poly(A) RNA binding | RBM42,CLNS1A,CSTF3,GM5506,UBC,HDGF,DHX16,TRIM28,EIF1AX,NCOA5 |
| calmodulin binding | MAP6,SNTA1,TTN,PHKG2,IQGAP3,KCNQ3,EDF1,PHKB,KCNN1,UBR4 |
| zinc ion binding | HE2,NUP153,EWSR1B,ZNF253,APOBEC3D,ZFAND5,ISL1,RBM4.1,DTNB,MMP28 |
| identical protein binding | TPD52L1,MPZL2B,TFRC,SLK,PCM1,MCIN,CRYAB,DIAP1,CCDC109A,FAM108A1 |
| protein binding | FOXM1,MGP,HRASLS5,AMY1A,THEM5,WTIP,SMAD3,PPP4R2,TEF,MYLK |
Interacting Protein
EWSR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EWSR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EWSR1.
MAPK1IP1L;PLSCR1;RASSF1;SEC24D;SEC24A;TRAF2
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References
- Soon, GST; Petersson, F; et al. Beware of immunohistochemistry - report of a cytokeratin-, desmin- and INI-1-negative pelvic desmoplastic small round cell tumor in a 51 year old woman. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:973-982(2015).
- Shibuya, R; Matsuyama, A; et al. The combination of CD99 and NKX2.2, a transcriptional target of EWSR1-FLI1, is highly specific for the diagnosis of Ewing sarcoma. VIRCHOWS ARCHIV 465:599-605(2014).
