EGLN3
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Official Full Name
egl-9 family hypoxia-inducible factor 3 -
Overview
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism. -
Synonyms
EGLN3;egl-9 family hypoxia-inducible factor 3;PHD3;HIFPH3;HIFP4H3;egl nine homolog 3;HPH-1;HPH-3;HIF-PH3;HIF prolyl hydroxylase 3;HIF-prolyl hydroxylase 3;egl nine-like protein 3 isoform;hypoxia-inducible factor prolyl hydroxylase 3;prolyl hydroxylase domain-containing protein 3
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
EGLN3 involved in several pathways and played different roles in them. We selected most pathways EGLN3 participated on our site, such as Cellular response to hypoxia,Cellular responses to stress,HIF-1 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGLN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular response to hypoxia | HIF3A,EPAS1B,EGLN2,EGLN1B,HIF1AL,HIF1AN |
| HIF-1 signaling pathway | AHA-1,EGLN2,CYBB |
| HIF-1-alpha transcription factor network | NDRG1,CITED2,ADM,TFF3,PLIN2,GATA2,NPM1,CP,ENG,COPS5 |
| Cellular responses to stress | HIST4H4,NUP35,H3F3B.1,HSBP1,TERF2IP,ATG9B,NUP50,RAD50,ATG101,TXNRD2 |
| Pathways in cancer | LPAR3,AKT2,FZD2,GNAI1,PIK3CD,GNG13,BIRC2,FLT3,GNG7,TRP53 |
| Regulation of Hypoxia-inducible Factor (HIF) by oxygen | HIF1AN,EGLN1B,EGLN2,HIF3A,HIF1AL,EPAS1B |
| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | EPAS1B,EGLN1B,HIF1AL,HIF3A,EGLN2 |
| HIF-2-alpha transcription factor network | HIF1AN,CITED2,EGLN2 |
Protein Function
EGLN3 has several biochemical functions, for example, L-ascorbic acid binding,iron ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by EGLN3 itself. We selected most functions EGLN3 had, and list some proteins which have the same functions with EGLN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | TMLHE,HBB,FTH1,CYP27B1,CYP46A1.1,CYP4V2,NFU1,CYP3A5,CYP27A1,CYP2AA4 |
| L-ascorbic acid binding | FAM125B,LEPREL2,PLOD3,EGLN1B,EGLN2,DBH,P4HTM,P4HA2,PLOD2,OGFOD2 |
| protein binding | CTR9,C14orf159,PCOLCE,IL1RN,FGFR4,EEF1A2,AP2S1,CALM1,SENP3,GADD45G |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | KDM5D,TYW5,P4HTM,ALKBH5,EGLN1,C14orf169,HIF1AN,KDM5C,ALKBH4,KDM5BB |
| peptidyl-proline 4-dioxygenase activity | EGLN1,EGLN2 |
Interacting Protein
EGLN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGLN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGLN3.
HIF1A;HIF1A;REL;SERTAD1;EFHC2;NCAPH2;TTC23L
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