DYRK1B
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Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B -
Overview
The DYRK family includes several dual-specificity tyrosine-phosphorylated and regulated kinases capable of phosphorylating proteins at both tyrosine and serine/threonine residues. The DYRK family was identified based on homology to the yeast Yak1 and the -
Synonyms
DYRK1B;dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B;dual specificity tyrosine-phosphorylation-regulated kinase 1B;minibrain related kinase;MIRK;mirk protein kinase;minibrain-related kinase
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- Insect Cell
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Insect cells
- In Vitro Cell Free System
- Insect (sf21)
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
DYRK1B involved in several pathways and played different roles in them. We selected most pathways DYRK1B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DYRK1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DYRK1B has several biochemical functions, for example, ATP binding,protein binding,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DYRK1B itself. We selected most functions DYRK1B had, and list some proteins which have the same functions with DYRK1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | YY1,MED16,NCOA1,MED13,SUPT7L,ATF2,RNF14,JUP,CTNNB1,PPARGC1A |
| protein serine/threonine/tyrosine kinase activity | TESK2,RPS6KA2,CLK1,RPS6KA1,AKT1,TNK2,TESK1,DYRK3,AURKA,DYRK1AA |
| protein kinase activity | ADRBK1,cka1,PRPF4BA,GC2,TRIOA,KITB,KITA,CDK5,ERBB4A,STK24 |
| protein binding | SPAG9,MYH7,TBX3,THBS2,PLCE1,HAND2,MTCH1,PCGF3,EMID2,SIRPB1 |
| ATP binding | TAOK3,AKT3,TRIOA,STK32B,SMARCA4,KITA,BBS10,MSH5,CASK,MAP2K2B |
| protein tyrosine kinase activity | Aatk,CLK2,DYRK2,FYNB,WEE1,CSF1RA,IGF1RA,PTK2AA,KDRL,RET |
| protein serine/threonine kinase activity | BCR,VRK3,CDK1,NLK2,PKN1B,GSK3A,CLK1,MOS,SNRKA,CSNK1G2 |
Interacting Protein
DYRK1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DYRK1B here. Most of them are supplied by our site. Hope this information will be useful for your research of DYRK1B.
HNF1A;RANBP9;DCAF7;RB1;RBL1;TROAP;LZTS2
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References
- Hickmott, J; et al. DYRK1B variant linked to autosomal dominant metabolic syndrome. CLINICAL GENETICS 87:30-31(2015).
- Foucourt, A; Hedou, D; et al. Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II. MOLECULES 19:15411-15439(2014).
