DUSP18
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Official Full Name
dual specificity phosphatase 18 -
Overview
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 -
Synonyms
DUSP18;dual specificity phosphatase 18;dual specificity protein phosphatase 18;DUSP20;LMWDSP20;Low molecular weight dual specificity phosphatase 20;LMW-DSP20;DSP18;bK963H5.1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DUSP18 involved in several pathways and played different roles in them. We selected most pathways DUSP18 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DUSP18 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,protein tyrosine phosphatase activity,protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP18 itself. We selected most functions DUSP18 had, and list some proteins which have the same functions with DUSP18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MAP kinase tyrosine/serine/threonine phosphatase activity | DUSP21,DUSP6,SGPP2,PTPRQ,SACM1L,DUSP2,DUSP1,SACM1LB,SACM1LA,DUSP14 |
| protein tyrosine/serine/threonine phosphatase activity | DUSP23,PTPDC1,MTMR2,NT5DC3,DUSP22A,SACM1L,PTPRQ,DUSP10,DUSP9,CDC14B |
| protein tyrosine phosphatase activity | DUSP19B,PTEN,PTPRA,EPM2A,DUPD1,PTPN14,MTMR2,PTPN11A,CDKN3,DUSP3 |
Interacting Protein
DUSP18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP18 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP18.
MAPK8IP2
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