DSG3
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Official Full Name
desmoglein 3 -
Overview
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008] -
Synonyms
DSG3;desmoglein 3;PVA;CDHF6;desmoglein-3;cadherin family member 6;pemphigus vulgaris antigen;130-kD pemphigus vulgaris antigen;130 kDa pemphigus vulgaris antigen
Recombinant Proteins
- Human
- Mouse
- Mammalian cells
- CHO
- E.coli
- Confidential
- Yeast
- Insect Cell
- Insect cells
- HEK293
- Fc
- His
- His&GST
- Non
- His&SUMO
- GST
- N-sumostar&C-His
- His&Fc&Avi
- His&Myc
Involved Pathway
DSG3 involved in several pathways and played different roles in them. We selected most pathways DSG3 participated on our site, such as Apoptosis,Apoptotic cleavage of cell adhesion proteins,Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Programmed Cell Death | DSP,DAPK3,DBNL,STK24,MLKL,RNF8,CASP6L1,DAPK1,GZMF,STK26 |
| Apoptosis | RIPK1,PRKACG,DIABLOA,NFKB1,PRKAR2AB,PPP3CCA,PIK3R3,CFLAR,E2F1,PIK3CG |
| Apoptotic cleavage of cellular proteins | DSG2,PLEC,CASP8L1,DBNLA,BCAP31,CLSPN,DBNL,OCLN,PTBP3,CASP6L1 |
| Apoptotic cleavage of cell adhesion proteins | CTNNB1,PTBP3,DSP,OCLN,PKP1,DSG2,DSG1,CTNNB2 |
| Apoptotic execution phase | HIST1H1A,SPNA2,PTBP3,HIST1H1E,PLEC,CASP6L1,OCLN,DBNLA,DNM1L,DSP |
Protein Function
DSG3 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG3 itself. We selected most functions DSG3 had, and list some proteins which have the same functions with DSG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH2G5,PCDH2AC,PPEF1,BMP1B,DGKG,PCDHA4,AIF1L,SPOCK3,SPOCK2,Shh |
Interacting Protein
DSG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG3.
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References
- Di Zenzo, G; Zambruno, G; et al. Clonal Analysis of B-Cell Response in Pemphigus Course: Toward More Effective Therapies. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:651-654(2015).
- Hammers, CM; Chen, J; et al. Persistence of Anti-Desmoglein 3 IgG(+) B-Cell Clones in Pemphigus Patients over Years. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:742-749(2015).
