DSG1

  • Official Full Name

    Desmoglein 1

  • Overview

    Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.

  • Synonyms

    DSG1;desmoglein 1;DGI;CDHF4;PPKS1;Cadherin family member 4;SPPK1;Desmosomal glycoprotein 1;DSG;Pemphigus foliaceus antigen;desmoglein-1;DG1;OTTHUMP00000162826;DSG2;desmoglein 2;HDGC;CDHF5;ARVC10;ARVD10;CMD1BB;MGC117034;MGC117036;MGC117037;Desmoglein-2

Recombinant Proteins

  • Human
  • E.coli
  • Mammalian cells
  • Wheat Germ
  • Confidential
  • In Vitro Cell Free System
  • Insect Cells
  • HEK293
  • His
  • Non
  • GST
  • His&GST
  • His&Myc
  • His&Myc&SUMO
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DSG1-12178H Recombinant Human DSG1 protein, His-tagged E.coli Human His 756-1049 aa
DSG1-1601H Recombinant Human Desmoglein 1 Mammalian cells Human Non
DSG1-26581TH Recombinant Human DSG1 Wheat Germ Human Non 1049 amino acids
DSG1-2890H Recombinant Human DSG1 Protein, GST-tagged Wheat Germ Human GST
DSG1-820H Recombinant Human DSG1 protein, His & GST-tagged E.coli Human His&GST Glu710~Val961
DSG1-8319H Recombinant Human DSG1 Mammalian cells Human Non
DSG1-512HCL Recombinant Human DSG1 cell lysate Human Non
DSG1-0269H Recombinant Human DSG1 Protein, Tag Free Confidential Human Non
DSG1-1388H Recombinant Human DSG1 Protein, His-tagged E.coli Human His Glu710-Val961
DSG1-144HF Recombinant Full Length Human DSG1 Protein In Vitro Cell Free System Human Full L. 1049 amino acids
DSG1-1794H Recombinant Human DSG1 protein(50-609aa), His-tagged E.coli Human His 50-609aa
DSG1-1994H Recombinant Human DSG1 Protein (Glu50-Pro548), N-His tagged E.coli Human His Glu50-Pro548
DSG1-2457H Recombinant Human DSG1 protein, His&Myc-tagged E.coli Human His&Myc 50-548aa
DSG1-2458H Recombinant Human DSG1 protein, His-SUMO & Myc-tagged E.coli Human His&Myc&SUMO 50-548aa
DSG1-2820H Recombinant Human DSG1 protein(391-540 aa), C-His-tagged E.coli Human His 391-540 aa
DSG1-4066H Recombinant Human DSG1 Protein (Glu50-Pro548), C-His tagged Insect Cells Human His Glu50-Pro548
DSG1-4067H Recombinant Human DSG1 Protein (Glu50-Pro548), C-His tagged Mammalian cells Human His Glu50-Pro548
DSG1-4254HF Recombinant Full Length Human DSG1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1049 amino acids
DSG1-4389H Recombinant Human DSG1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
DSG1-4389H-B Recombinant Human DSG1 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    DSG1 involved in several pathways and played different roles in them. We selected most pathways DSG1 participated on our site, such as Apoptosis,Apoptotic cleavage of cell adhesion proteins,Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptotic cleavage of cell adhesion proteins PKP1,PTBP3,DSG2,CTNNB2,DSG3,OCLN,DSP,CTNNB1
    Apoptosis CASP8,TNFRSF10C,HRK,PPP3CA,PRKAR1A,PRKACA,DIABLOB,CAPN1B,IRF2A,TNFSF10
    Apoptotic cleavage of cellular proteins PLEC,DSG2,PKP1,STK24,SATB1,SPNA2,BMX,OCLN,ADD1,GAS2
    Programmed Cell Death DNM1L,DBNLA,STK24,HMGB2A,SATB1,STK26,CASP6L2,PANK1A,CASP6L1,VIML
    Staphylococcus aureus infection MASP1,ITGB2,MBL1,FGG,C1QC,HLA-DRB4,HLA-DRB1,FCGR3B,HLA-DPB1,ICAM1
    Apoptotic execution phase DBNL,CLSPN,VIML,SATB1,DSP,CASP6L1,CASP6L2,DNM1L,PLECA,STK24

    Protein Function

    DSG1 has several biochemical functions, for example, calcium ion binding,gamma-catenin binding,toxic substance binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG1 itself. We selected most functions DSG1 had, and list some proteins which have the same functions with DSG1. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding DSG4,PCDH2G8,C1S,PRRG4,AASS,PCDH2G3,NOTCH3,PLA2G2F,PCDH2AB9,SYT11
    gamma-catenin binding CDH1,LEF1,PTPRK,CDH2,DSG1A,TCF7L2,Fert2,APC,FER,PTBP3
    toxic substance binding A4GALT,GUCY2C,CHRNA7,AZU1,H2-AB1,Alb,NEFH,ASS1,PHAX,EPHX2

    Interacting Protein

    DSG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG1.

    SSSCA1;USP1;GH1;OTUD4;USP53;VRK3;q9nz47_human;RUVBL1;midostaurin;cona_canen;ESR1;CFTR;IQGAP1;PLK1;CD81;GABARAPL2;PPP2R2B;MAPK7;IQCB1

    Resources

    Research Area

    Cadherin Superfamily

    References

    • Aoki, V; Rivitti, EA; et al. Update on fogo selvagem, an endemic form of pemphigus foliaceus. JOURNAL OF DERMATOLOGY 42:18-26(2015).
    • Kinjyo, C; Kaneko, T; et al. Oral lichen planus with antibodies to desmogleins 1 and 3. JOURNAL OF DERMATOLOGY 42:40-41(2015).

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