DOHH
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Official Full Name
deoxyhypusine hydroxylase/monooxygenase -
Overview
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants. -
Synonyms
DOHH;deoxyhypusine hydroxylase/monooxygenase;HEAT like (PBS lyase) repeat containing 1 , HLRC1;deoxyhypusine hydroxylase;MGC4293;Deoxyhypusine dioxygenase;Deoxyhypusine monooxygenase;hDOHH;HEAT like PBS lyase repeat containing;HEAT like repeat containing protein 1;HEAT-like repeat-containing protein 1;HEAT-like (PBS lyase) repeat containing 1;HLRC1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DOHH involved in several pathways and played different roles in them. We selected most pathways DOHH participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation,Hypusine synthesis from eIF5A-lysine,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOHH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypusine synthesis from eIF5A-lysine | EIF5A2,EIF5A,DHPS |
| hypusine biosynthesis | DHPS |
| Post-translational protein modification | B3GNT6,BET1,DPAGT1,ADAMTS1,ADAMTS13,NSMCE1,TRAPPC6A,ARSI,MGAT4B,MUC15 |
| Metabolism of proteins | TIMM21,DPAGT1,EEF1A2,EEF1D,EXOSC8,IGFBP1A,MGAT4A,TRAPPC6A,IGFBP5A,NANP |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | F9A,DPH1,ARSH,GAS6,F9B,ARSE,DNAJC24,PROCA,DHPS,EIF5A |
Protein Function
DOHH has several biochemical functions, for example, deoxyhypusine monooxygenase activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOHH itself. We selected most functions DOHH had, and list some proteins which have the same functions with DOHH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ATP1A1A.5,C1GALT1,ZNF32,ZNF691,ZFP787,ZFP639,Car14,MGRN1B,U2AF1L4,ZFP385C |
| protein binding | ZNF295,CCNB1IP1,CLNK,MXD1,ANKMY2,TIMM10,NPAS2,DERL1,UTP3,ZC3HC1 |
Interacting Protein
DOHH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOHH here. Most of them are supplied by our site. Hope this information will be useful for your research of DOHH.
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References
- Zappasodi, R; Bongarzone, I; et al. Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target. BLOOD 118:4421-4430(2011).
- Sgier, D; Zuberbuehler, K; et al. Isolation and characterization of an inhibitory human monoclonal antibody specific to the urokinase-type plasminogen activator, uPA. PROTEIN ENGINEERING DESIGN & SELECTION 23:261-269(2010).
